p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control



: Eskelinen Eeva-Liisa, Kageyama Shun, Komatsu Masaaki

Publisher: TAYLOR & FRANCIS INC

: 2021

: Molecular & Cellular Oncology

: MOLECULAR & CELLULAR ONCOLOGY

: MOL CELL ONCOL

: ARTN 1890990

: 8

: 2

: 3

DOI: https://doi.org/10.1080/23723556.2021.1890990

: https://research.utu.fi/converis/portal/detail/Publication/53412717


Selective autophagy contributes to the degradation of condensates, such as sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous p62 forms gel-like structures, which serve as platforms for autophagosome formation and nuclear factor erythroid 2-related factor 2 (NRF2) activation. Further, p62-mediated NRF2 activation is not cytotoxic, but combination of NRF2 activation with impaired bulk and selective autophagy causes liver injury.

Last updated on 2024-26-11 at 13:59