B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä
p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control
Tekijät: Eskelinen Eeva-Liisa, Kageyama Shun, Komatsu Masaaki
Kustantaja: TAYLOR & FRANCIS INC
Julkaisuvuosi: 2021
Journal: Molecular & Cellular Oncology
Tietokannassa oleva lehden nimi: MOLECULAR & CELLULAR ONCOLOGY
Lehden akronyymi: MOL CELL ONCOL
Artikkelin numero: ARTN 1890990
Vuosikerta: 8
Numero: 2
Sivujen määrä: 3
DOI: https://doi.org/10.1080/23723556.2021.1890990
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/53412717
Selective autophagy contributes to the degradation of condensates, such as sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous p62 forms gel-like structures, which serve as platforms for autophagosome formation and nuclear factor erythroid 2-related factor 2 (NRF2) activation. Further, p62-mediated NRF2 activation is not cytotoxic, but combination of NRF2 activation with impaired bulk and selective autophagy causes liver injury.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
