B1 Vertaisarvioimaton kirjoitus tieteellisessä lehdessä
p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control
Tekijät: Eskelinen Eeva-Liisa, Kageyama Shun, Komatsu Masaaki
Kustantaja: TAYLOR & FRANCIS INC
Julkaisuvuosi: 2021
Lehti: Molecular & Cellular Oncology
Tietokannassa oleva lehden nimi: MOLECULAR & CELLULAR ONCOLOGY
Lehden akronyymi: MOL CELL ONCOL
Artikkelin numero: ARTN 1890990
Vuosikerta: 8
Numero: 2
Sivujen määrä: 3
DOI: https://doi.org/10.1080/23723556.2021.1890990
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/53412717
Selective autophagy contributes to the degradation of condensates, such as sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous p62 forms gel-like structures, which serve as platforms for autophagosome formation and nuclear factor erythroid 2-related factor 2 (NRF2) activation. Further, p62-mediated NRF2 activation is not cytotoxic, but combination of NRF2 activation with impaired bulk and selective autophagy causes liver injury.
Avainsanat:
GABARAP, KEAP1, LC3, liquid-liquid phase separation, NRF2, p62/SQSTM1
Ladattava julkaisu This is an electronic reprint of the original article. |  |
