B1 Non-refereed article in a scientific journal
p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control
Authors: Eskelinen Eeva-Liisa, Kageyama Shun, Komatsu Masaaki
Publisher: TAYLOR & FRANCIS INC
Publication year: 2021
Journal: Molecular & Cellular Oncology
Journal name in source: MOLECULAR & CELLULAR ONCOLOGY
Journal acronym: MOL CELL ONCOL
Article number: ARTN 1890990
Volume: 8
Issue: 2
Number of pages: 3
DOI: https://doi.org/10.1080/23723556.2021.1890990
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/53412717
Abstract
Selective autophagy contributes to the degradation of condensates, such as sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous p62 forms gel-like structures, which serve as platforms for autophagosome formation and nuclear factor erythroid 2-related factor 2 (NRF2) activation. Further, p62-mediated NRF2 activation is not cytotoxic, but combination of NRF2 activation with impaired bulk and selective autophagy causes liver injury.
Selective autophagy contributes to the degradation of condensates, such as sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous p62 forms gel-like structures, which serve as platforms for autophagosome formation and nuclear factor erythroid 2-related factor 2 (NRF2) activation. Further, p62-mediated NRF2 activation is not cytotoxic, but combination of NRF2 activation with impaired bulk and selective autophagy causes liver injury.
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