Saku Ruohonen
 PhD, Adjunct Professor of Pharmacology

  

  

  

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• TV viewing and subclinical cardiac diastolic dysfunction in early midlife. The Cardiovascular Risk in Young Finns Study.  (2016)   Helajärvi H, Ruohonen S, Pahkala K, Heinonen OJ, Viikari J, Raitakari OT

  
  

• Neuropeptide Y in the noradrenergic neurones induces obesity and inhibits sympathetic tone in mice. – Noradrenergic neurone NPY and obesity  (2015)  
  • Acta Physiologica
   Vähätalo LH, Ruohonen ST, Mäkelä S, Kovalainen M, Huotari A, Mäkelä KA, Määttä JA, Miinalainen I, Gilsbach R, Hein L, Ailanen L, Mattila M, Eerola K, Röyttä M, Ruohonen S, Herzig KH, Savontaus E

  
  

• Subtle increases in heart size persist into adulthood in growth restricted babies: the Cardiovascular Risk in Young Finns Study.  (2015)  
  • Open Heart
   Clare Arnott, Michael R Skilton, Saku Ruohonen, Markus Juonala, Jorma S A Viikari, Mika Kähönen, Terho Lehtimäki, Tomi Laitinen, David S Celermajer, Olli T Raitakari

  
  

• The effects of equal caloric high fat and western diet on metabolic syndrome, oxidative stress and vascular endothelial function in mice  (2014)  
  • Acta Physiologica
   I. Heinonen, P. Rinne, S. T. Ruohonen, S. Ruohonen, M. Ahotupa, E. Savontaus

  
  

• A polymorphism in the protein kinase C gene PRKCB is associated with alpha(2)-adrenoceptor-mediated vasoconstriction  (2013)  
  • Pharmacogenetics and Genomics
   Posti JP, Salo P, Ruohonen S, Valve L, Muszkat M, Sofowora GG, Kurnik D, Stein CM, Perola M, Scheinin M, Snapir A

  
  

• Lentivirus-Mediated alpha-Melanocyte-Stimulating Hormone Overexpression in the Hypothalamus Decreases Diet Induced Obesity in Mice  (2013)  
  • Journal of Neuroendocrinology
   Eerola K, Nordlund W, Virtanen S, Dickens AM, Mattila M, Ruohonen ST, Chua SC Jr, Wardlaw SL, Savontaus M, Savontaus E

  
  

• Pharmacological treatment with a melanocortin analogue protects against pressure-overload-induced cardiac hypertrophy  (2013)  
  • FASEB Journal
  Faseb Journal Rinne P, Ruohonen ST, Ruohonen S, Savontaus E

  
  

• Status epilepticus alters neurogenesis and decreases the number of GABAergic neurons in the septal dentate gyrus of 9-day-old rats at the early phase of epileptogenesis  (2013)  
  • Brain Research
   Lauren HB, Ruohonen S, Kukko-Lukjanov TK, Virta JE, Gronman MA, Lopez-Picon FR, Jarvela JT, Holopainen IE

  
  

• α-Melanocyte-stimulating hormone regulates vascular NO availability and protects against endothelial dysfunction  (2013)  
  • Cardiovascular Research
   Petteri Rinne, Wendy Nordlund, Ilkka Heinonen, Anna-Maija Penttinen, Antti Saraste, Suvi T. Ruohonen, Satu Mäkelä, Laura Vähätalo, Katja Kaipio, Minying Cai, Victor J. Hruby, Saku Ruohonen, Eriika Savontaus

  
  

• Involvement of α2-adrenoceptor subtypes A and C in glucose homeostasis and adrenaline-induced hyperglycaemia.  (2012)  
  • Neuroendocrinology
   Ruohonen ST, Ruohonen S, Gilsbach R, Savontaus E, Scheinin M, Hein L

  
  

• Neuropeptide Y in the noradrenergic neurons induces the development of cardiometabolic diseases in a transgenic mouse model  (2012)   Ruohonen Saku Tuomas, Pesonen Ullamari, Savontaus Eriika

  
  

• Dietary sodium modulates the interaction between efferent and afferent renal nerve activity by altering activation of α2-adrenoceptors on renal sensory nerves  (2011)  
  • AJP - Regulatory, Integrative and Comparative Physiology
   Kopp UC, Cicha MZ, Smith LA, Ruohonen S, Scheinin M, Fritz N, Hökfelt T

  
  

• Dorsal hand vein responses to the α₁-adrenoceptor agonist phenylephrine do not predict responses to the α₂-adrenoceptor agonist dexmedetomidine.  (2011)  
  • European Journal of Pharmacology
   Posti JP, Valve L, Ruohonen S, Akkila J, Scheinin M, Snapir A

  
  

• Kainic acid-induced neurodegeneration and activation of inflammatory processes in organotypic hippocampal slice cultures: Treatment with cyclooxygenase-2 inhibitor does not prevent neuronal death  (2011)  
  • Neuropharmacology
   Jarvela JT, Ruohonen S, Kukko-Lukjanov TK, Plysjuk A, Lopez-Picon FR, Holopainen IE

  
  

• Temporal profiles of age-dependent changes in cytokine mRNA expression and glial cell activation after status epilepticus in postnatal rat hippocampus  (2011)  
  • Journal of Neuroinflammation
   Jarvela JT, Lopez-Picon FR, Plysjuk A, Ruohonen S, Holopainen IE

  
  

• Sympathetic nervous system-targeted neuropeptide Y overexpression in mice enhances neointimal formation in response to vascular injury.  (2009)  
  • Peptides
   Ruohonen ST, Abe K, Kero M, Toukola L, Ruohonen S, Röyttä M, Koulu M, Pesonen U, Zukowska Z, Savontaus E

  
  

• Cytokine responses during chronic denervation.  (2005)  
  • Journal of Neuroinflammation
   Ruohonen S, Khademi M, Jagodic M, Taskinen HS, Olsson T, Röyttä M

  
  

• Distinct expression of TGF-beta1 mRNA in the endo- and epineurium after nerve injury.  (2004)  
  • Journal of Neurotrauma
   Taskinen HS, Ruohonen S, Jagodic M, Khademi M, Olsson T, Röyttä M

  
  

• Bioplasticity after peripheral nerve injury  (2003)   Röyttä M, Taskinen H-S, Siironen J, Vuorinen V, Ruohonen S

  
  

• Contralateral non-operated nerve to transected rat sciatic nerve shows increased expression of IL-1beta, TGF-beta1, TNF-alpha, and IL-10.  (2002)  
  • Journal of Neuroimmunology
   Ruohonen S, Jagodi M, Khademi M, Taskinen HS, Ojala P, Olsson T, Röyttä M