α-Melanocyte-stimulating hormone regulates vascular NO availability and protects against endothelial dysfunction
: Petteri Rinne, Wendy Nordlund, Ilkka Heinonen, Anna-Maija Penttinen, Antti Saraste, Suvi T. Ruohonen, Satu Mäkelä, Laura Vähätalo, Katja Kaipio, Minying Cai, Victor J. Hruby, Saku Ruohonen, Eriika Savontaus
Publisher: OXFORD UNIV PRESS
: 2013
: Cardiovascular Research
: CARDIOVASCULAR RESEARCH
: Cardiovasc Res
: 2
: 97
: 2
: 360
: 368
: 9
: 0008-6363
: 1755-3245
DOI: https://doi.org/10.1093/cvr/cvs335
The present study identifies -MSH and endothelial MC1 receptors as a new signalling pathway contributing to the regulation of NO availability and vascular function. These findings suggest applicability of -MSH analogues for therapeutic use in pathological conditions that are characterized by vascular dysfunction.
