PhD, Adjunct Professor of Pharmacology Saku Ruohonen - UTU Research Portal

Saku Ruohonen
PhD, Adjunct Professor of Pharmacology

- Docent,
Institute of Biomedicine (Faculty of Medicine)

saturu@utu.fi

ORCID identifier: https://orcid.org/0000-0003-2503-148X

Areas of expertise

Pharmacology and toxicology. Cardiovascular sciences in preclinical and epidemiological studies.

Publications

1 of 2

Melanocortin 1 Receptor Regulates Pathological and Physiological Cardiac Remodeling (2025)
- Journal of the American Heart Association
Suominen, Anni; Suni, Aino; Ruohonen, Saku; Szabó, Zoltán; Pohjolainen, Lotta; Cai, Minying; Savontaus, Eriika; Talman, Virpi; Kerkelä, Risto; Rinne, Petteri
(A1 Refereed original research article in a scientific journal)
Determinants of echocardiographic epicardial adipose tissue in a general middle-aged population - The Cardiovascular Risk in Young Finns Study (2024)
- Scientific Reports
Gustafsson, Behnoush; Rovio, Suvi P.; Ruohonen, Saku; Hutri-Kähönen, Nina; Kähönen, Mika; Viikari, Jorma S. A.; Pahkala, Katja; Raitakari, Olli T.
(A1 Refereed original research article in a scientific journal)
Exploring machine learning strategies for predicting cardiovascular disease risk factors from multi-omic data (2024)
- BMC Medical Informatics and Decision Making
Drouard Gabin, Mykkänen Juha, Heiskanen Jarkko, Pohjonen Joona, Ruohonen Saku, Pahkala Katja, Lehtimäki Terho, Wang Xiaoling, Ollikainen Miina, Ripatti Samuli, Pirinen Matti, Raitakari Olli, Kaprio Jaakko
(A1 Refereed original research article in a scientific journal)
Exposure to parental smoking and cardiac structure and function in adulthood: the Cardiovascular Risk in Young Finns Study (2024)
- Scandinavian Journal of Public Health
Pihlman Jukka, Nuotio Joel, Rovio Suvi, Pahkala Katja, Ruohonen Saku, Jokinen Eero, Laitinen Tomi P, Burgner David P, Hutri-Kähönen Nina, Tossavainen Päivi, Taittonen Leena, Kähönen Mika, Viikari Jorma SA, Raitakari Olli T, Magnussen Costan G, Juonala Markus
(A1 Refereed original research article in a scientific journal)
α-Melanocyte-stimulating hormone alleviates pathological cardiac remodeling via melanocortin 5 receptor (2024)
- EMBO Reports
Suominen Anni, Saldo Rubio Guillem, Ruohonen Saku, Szabó Zoltan, Pohjolainen Lotta, Ghimire Bishwa, Ruohonen Suvi T., Saukkonen Karla, Ijas Jani, Skarp Sini, Kaikkonen Leena, Cai Minying, Wardlaw Sharon L., Ruskoaho Heikki, Talman Virpi, Savontaus Eriika, Kerkelä Risto, Rinne Petteri
(A1 Refereed original research article in a scientific journal)
Deep Learning–Based Segmentation of Morphologically Distinct Rat Hippocampal Reactive Astrocytes After Trimethyltin Exposure (2022)
- Toxicologic Pathology
Vuorimaa Miika, Kareinen Ilona, Toivanen Petri, Karlsson Stefan, Ruohonen Saku

(A1 Refereed original research article in a scientific journal)
Cardiovascular Risk Factors in Childhood and Left Ventricular Diastolic Function in Adulthood (2021)
- Pediatrics
Heiskanen Jarkko S, Ruohonen Saku, Rovio Suvi P, Pahkala Katja, Kytö Ville, Kähonen Mika, Lehtimäki Terho, Viikari Jorma SA, Juonala Markus, Laitinen Tomi, Tossavainen Päivi, Jokinen Eero, Hutri-Kähönen Nina, Raitakari Olli T
(A1 Refereed original research article in a scientific journal)
Fatty liver index and left ventricular mass: prospective associations from two independent cohorts (2021)
- Journal of Hypertension
Li Xiang, Heiskanen Jarkko S, Ma Hao, Heianza Yoriko, Guo Yajun, Kelly Tanika N, He Hua, Fonseca Vivian A, Chen Wei, Harville Emily W, Ruohonen Saku, Hutri-Kähönen Nina, Bazzano Lydia A, Raitakari Olli T, Qi Lu
(A1 Refereed original research article in a scientific journal)
Influence of early-life body mass index and systolic blood pressure on left ventricle in adulthood - the Cardiovascular Risk in Young Finns Study (2021)
- Annals of Medicine
Heiskanen Jarkko S, Hernesniemi Jussi A, Ruohonen Saku, Hutri-Kähönen Nina, Kähonen Mika, Jokinen Eero, Tossavainen Päivi, Kallio Merja, Laitinen Tomi, Lehtimäki Terho, Viikari Jorma, Juonala Markus, Nevalainen Jaakko, Raitakari Olli T
(A1 Refereed original research article in a scientific journal)
Childhood Psychosocial Environment and Adult Cardiac Health: A Causal Mediation Approach (2019)
- American Journal of Preventive Medicine
Komulainen K, Mittleman MA, Ruohonen S, Laitinen TT, Pahkala K, Elovainio M, Tammelin T, Kähönen M, Juonala M, Keltikangas-Järvinen L, Raitakari O, Pulkki-Råback L, Jokela M
(A1 Refereed original research article in a scientific journal)
Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress (2019)
- Scientific Reports
Nicole C . A. van Engeland, Freddy Suarez Rodriguez, Adolfo Rivero-Müller, Tommaso Ristori, Camille L. Duran, Oscar M. J. A. Stassen, Daniel Antfolk, Rob C. H. Driessen, Saku Ruohonen, Suvi T. Ruohonen, Salla Nuutinen,
Eriika Savontaus, Sandra Loerakker, Kayla J. Bayless, Marika Sjöqvist, Carlijn V. C . Bouten, John E. Eriksson, Cecilia M. Sahlgren
(A1 Refereed original research article in a scientific journal)
Aortic sinus diameter in middle age is associated with body size in young adulthood (2018)
- Heart
Hernesniemi JA, Heiskanen J, Ruohonen S, Kartiosuo N, Hutri-Kähönen N, Kähönen M, Jokinen E, Tossavainen P, Kallio M, Laitinen T, Lehtimäki T, Viikari JSA, Juonala M, Raitakari OT
(A1 Refereed original research article in a scientific journal)
Geographic origin as a determinant of left ventricular mass and diastolic function – the Cardiovascular Risk in Young Finns Study (2018)
- Scandinavian Journal of Public Health
L. Vähämurto, M. Juonala, S. Ruohonen, N. Hutri-Kähönen, M. Kähönen, T. Laitinen, P. Tossavainen, E. Jokinen, J. Viikari, O.T. Raitakari, K. Pahkala
(A1 Refereed original research article in a scientific journal)
Reference values and correlates of right atrial volume in healthy adults by two-dimensional echocardiography. (2018)
- Echocardiography
Ferrara F, Gargani L, Ruohonen S, Vriz O, Scalese M, Russo V, Marra AM, Stanziola AA, Cittadini A, D'Andrea A, Naeije R, Bossone E.
(A1 Refereed original research article in a scientific journal)
Association of Socioeconomic Status in Childhood With Left Ventricular Structure and Diastolic Function in Adulthood The Cardiovascular Risk in Young Finns Study (2017)
- JAMA Pediatrics
Laitinen TT, Puolakka E, Ruohonen S, Magnussen CG, Smith KJ, Viikari JSA, Heinonen OJ, Kartiosuo N, Hutri-Kahonen N, Kahonen M, Jokinen E, Laitinen TP, Tossavainen P, Pulkki-Raback L, Elovainio M, Raitakari OT, Pahkala K, Juonala M
(A1 Refereed original research article in a scientific journal)
Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure (2017)
- Journal of the American Heart Association
Marques FZ, Prestes PR, Byars SG, Ritchie SC, Wurtz P, Patel SK, Booth SA, Rana I, Minoda Y, Berzins SP, Curl CL, Bell JR, Wai B, Srivastava PM, Kangas AJ, Soininen P, Ruohonen S, Kahonen M, Lehtimaki T, Raitoharju E, Havulinna A, Perola M, Raitakari O, Salomaa V, Ala-Korpela M, Kettunen J, McGlynn M, Kelly J, Wlodek ME, Lewandowski PA, Delbridge LM, Burrell LM, Inouye M, Harrap SB, Charchar FJ, Harrap SB, Charchar FJ
(A1 Refereed original research article in a scientific journal)
Ideal cardiovascular health in childhood-Longitudinal associations with cardiac structure and function: The Special Turku Coronary Risk Factor Intervention Project (STRIP) and the Cardiovascular Risk in Young Finns Study (YFS) (2017)
- International Journal of Cardiology
Laitinen TT, Ruohonen S, Juonala M, Magnussen CG, Mikkila V, Mikola H, Hutri-Kahonen N, Laitinen T, Tossavainen P, Jokinen E, Niinikoski H, Jula A, Viikari JSA, Ronnemaa T, Raitakari OT, Pahkala K
(A1 Refereed original research article in a scientific journal)
Reference Values for Echocardiography in Middle-Aged Population: The Cardiovascular Risk in Young Finns Study. (2016)
- Echocardiography
Ruohonen S, Koskenvuo JW, Wendelin-Saarenhovi M, Savontaus M, Kähönen M, Laitinen T, Lehtimäki T, Jokinen E, Viikari J, Juonala M, Taittonen L, Tossavainen P, Kallio M, Bax JJ, Raitakari O.
(A1 Refereed original research article in a scientific journal)
Systemic Dosing of Thymosin Beta 4 before and after Ischemia Does Not Attenuate Global Myocardial Ischemia-Reperfusion Injury in Pigs (2016)
- Frontiers in Pharmacology
Stark CKJ, Tarkia M, Kentala R, Malmberg M, Vahasilta T, Savo M, Hynninen VV, Helenius M, Ruohonen S, Jalkanen J, Taimen P, Alastalo TP, Saraste A, Knuuti J, Savunen T, Koskenvuo J
(A1 Refereed original research article in a scientific journal)
TV viewing and subclinical cardiac diastolic dysfunction in early midlife. The Cardiovascular Risk in Young Finns Study. (2016) Helajärvi H, Ruohonen S, Pahkala K, Heinonen OJ, Viikari J, Raitakari OT
(Other publication)