Temporal profiles of age-dependent changes in cytokine mRNA expression and glial cell activation after status epilepticus in postnatal rat hippocampus



: Jarvela JT, Lopez-Picon FR, Plysjuk A, Ruohonen S, Holopainen IE

Publisher: BIOMED CENTRAL LTD

: 2011

: Journal of Neuroinflammation

: JOURNAL OF NEUROINFLAMMATION

: J NEUROINFLAMM

: ARTN 29

: 8

: 12

: 1742-2094

DOI: https://doi.org/10.1186/1742-2094-8-29


Conclusion: Our results suggest that SE provokes an age-specific cytokine expression in the acute phase, and age-specific glial cell activation in the subacute phase as verified now in the postnatal rat hippocampus. In the juvenile hippocampus, transient increases in cytokine mRNA expression after SE, in contrast to prolonged glial reactivity and region-specific microglial activity after SE, suggest that the inflammatory response is changed from a fulminant and general initial phase to a more moderate and specific subacute response.



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