Ph.D. Matej Oresic - UTU Research Portal

Matej Oresic
Ph.D.

- Professor,
Turku Bioscience Centre (Independent units)
- ,
InFLAMES Flagship (Faculty of Medicine)

matej.oresic@utu.fi

+358 29 450 3798

+358 46 923 3395

Tykistökatu 6

Turku

: https://orcid.org/0000-0002-2856-9165

Systems Medicine group

Google Scholar

Systems biology, exposome, bioinformatics, metabolomics, lipidomics, biophysics, systems medicine, computational biology

Professor Matej Orešič holds a PhD in biophysics from Cornell University (1999; Ithaca, NY, USA). He is professor of medicine, with specialization in systems medicine at Örebro University (Sweden) and a professor of biochemistry (metabolomics) at the University of Turku (Finland). Prof. Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. As of 2016, he was made a Lifetime Honorary Fellow of the Metabolomics Society. Professor Orešič currently serves as member of the Board of Directors of the Metabolomics Society and is one of the founders of the Nordic Metabolomics Society, previously serving as its chair of the board. In 2019, he co-chaired the 1st Gordon Research Conference on ‘Metabolomics and Human Health’ (Ventura, CA, USA). Previously, he also chaired the Keystone Symposium on Systems Biology of Lipid Metabolism (2015; Breckenridge, CO, USA). Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.

Professor Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.

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(2015)
- Diabetologia
Marinkovic T, Hyotylainen T, Mattila I, Poho P, Knip M, Oresic M
Analytical Lipidomics in Metabolic and Clinical Research (2015)
- Trends in Endocrinology and Metabolism
Hyotylainen T, Oresic M
Bioactive lipids dissociate steatosis and insulin resistance in the human liver in non-alcoholic fatty liver disease (2015)
- Diabetologia
Luukkonen P, Zhou Y, Sadevirta S, Leivonen M, Arola J, Oresic M, Hyotylainen T, Yki-Jarvinen H
Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2 (2015)
- Journal of Hepatology
Zhou Y, Llaurado G, Oresic M, Hyotylainen T, Orho-Melander M, Yki-Jarvinen H
2015
- Metabolomics
Reza M. Salek, Steffen Neumann, Daniel Schober, Jan Hummel, Kenny Billiau, Joachim Kopka, Elon Correa, Theo Reijmers, Antonio Rosato, Leonardo Tenori, Paola Turano, Silvia Marin, Catherine Deborde, Daniel Jacob, Dominique Rolin, Benjamin Dartigues, Pablo Conesa, Kenneth Haug, Philippe Rocca-Serra, Steve O’Hagan, Jie Hao, Michael van Vliet, Marko Sysi-Aho, Christian Ludwig, Jildau Bouwman, Marta Cascante, Timothy Ebbels, Julian L. Griffin, Annick Moing, Macha Nikolski, Matej Oresic, Susanna-Assunta Sansone, Mark R. Viant, Royston Goodacre, Ulrich L. Günther, Thomas Hankemeier, Claudio Luchinat, Dirk Walther, Christoph Steinbeck
Erratum to: Coordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access (vol 11, pg 1587, 2015) (2015)
- MetabolomicsBritish Journal of Clinical Pharmacology
Reza M. Salek, Steffen Neumann, Daniel Schober, Jan Hummel, Kenny Billiau, Joachim Kopka, Elon Correa, Theo Reijmers, Antonio Rosato, Leonardo Tenori, Paola Turano, Silvia Marin, Catherine Deborde, Daniel Jacob, Dominique Rolin, Benjamin Dartigues, Pablo Conesa, Kenneth Haug, Philippe Rocca-Serra, Steve O’Hagan, Jie Hao, Michael van Vliet, Marko Sysi-Aho, Christian Ludwig, Jildau Bouwman, Marta Cascante, Timothy Ebbels, Julian L. Griffin, Annick Moing, Macha Nikolski, Matej Oresic, Susanna-Assunta Sansone, Mark R. Viant, Royston Goodacre, Ulrich L. Günther, Thomas Hankemeier, Claudio Luchinat, Dirk Walther, Christoph Steinbeck
(2015)
- Diabetes
Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A, Relat J, Cuadrado I, Pellegrinelli V, Medina-Gomez G, Lopez-Pedrera C, Tinahones FJ, Symons JD, Summers SA, Oresic M, Vidal-Puig A
Optimizing the lipidomics workflow for clinical studies-practical considerations (2015)
- Analytical and Bioanalytical ChemistryPLoS ONE
Hyötyläinen T, Oresic M
(2015)
- PLoS ONEDiabetes
Tulika Arora , Vidya Velagapudi , Dimitri J. Pournaras, Richard Welbourn, Carel W. le Roux, Matej Orešič, Fredrik Bäckhed
(2015)
- NeurocomputingProgress in Lipid Research
T. Vatanen, M. Osmala, T. Raiko, K. Lagus, M. Sysi-Aho, M. Orešič, T. Honkela, H. Lähdesmäki
Serum Lipid and Serum Metabolite Components in relation to anthropometric parameters in EPIC-Potsdam participantsCord Serum Lipidome in Prediction of Islet Autoimmunity and Type 1 Diabetes2015
- MetabolismDiabetes
Jana Foerster, Tuulia Hyötyläinen, Matej Oresic, Heli Nygren, Heiner Boeing
(2015)
- Cell Host and MicrobeArteriosclerosis, Thrombosis, and Vascular Biology
Kostic AD, Gevers D, Siljander H, Vatanen T, Hyotylainen T, Hamalainen AM, Peet A, Tillmann V, Poho P, Mattila I, Lahdesmaki H, Franzosa EA, Vaarala O, de Goffau M, Harmsen H, Ilonen J, Virtanen SM, Clish CB, Oresic M, Huttenhower C, Knip M, Xavier RJ
2015
Hukkanen J, Puurunen J, Hyotylainen T, Savolainen MJ, Ruokonen A, Morin-Papunen L, Oresic M, Piltonen T, Tapanainen JS
The influence of sample collection methodology and sample preprocessing on the blood metabolic profile (2015)
- Bioanalysis
Jorgenrud B, Jantti S, Mattila I, Poho P, Ronningen KS, Yki-Jarvinen H, Oresic M, Hyotylainen T
The Metabolome in Finnish Carriers of the MYBPC3-Q1061X Mutation for Hypertrophic Cardiomyopathy (2015)
Benedicte Jørgenrud, Mikko Jalanko, Tiina Heliö, Pertti Jääskeläinen, Mika Laine, Mika Hilvo, Markku S. Nieminen, Markku Laakso, Tuulia Hyötyläinen, Matej Orešič, Johanna Kuusisto
Circulating Triacylglycerol Signatures in Nonalcoholic Fatty Liver Disease Associated With the I148M Variant in PNPLA3 and With Obesity (2014)
Hyysalo J, Gopalacharyulu P, Bian H, Hyotylainen T, Leivonen M, Jaser N, Juuti A, Honka MJ, Nuutila P, Olkkonen VM, Oresic M, Yki-Jarvinen H
Systems biology strategies to study lipidomes in health and disease (2014)
Hyotylainen T, Oresic M
(2013)
Oresic M, Gopalacharyulu P, Mykkänen J, Lietzen N, Mäkinen M, Nygren H, Simell S, Simell V, Hyöty H, Veijola R, Ilonen J, Sysi-Aho M, Knip M, Hyötyläinen T, Simell O
Genomic, Transcriptomic, and Lipidomic Profiling Highlights the Role of Inflammation in Individuals With Low High-density Lipoprotein Cholesterol (2013)
Laurila PP, Surakka I, Sarin AP, Yetukuri L, Hyotylainen T, Soderlund S, Naukkarinen J, Tang J, Kettunen J, Mirel DB, Soronen J, Lehtimaki T, Ruokonen A, Ehnholm C, Eriksson JG, Salomaa V, Jula A, Raitakari OT, Jarvelin MR, Palotie A, Peltonen L, Oresic M, Jauhiainen M, Taskinen MR, Ripatti S
Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids (2013)
- Diabetologia
Oresic M, Hyotylainen T, Kotronen A, Gopalacharyulu P, Nygren H, Arola J, Castillo S, Mattila I, Hakkarainen A, Borra RJH, Honka MJ, Verrijken A, Francque S, Iozzo P, Leivonen M, Jaser N, Juuti A, Sorensen TIA, Nuutila P, Van Gaal L, Yki-Jarvinen H