Ph.D. Matej Oresic - UTU Research Portal

Matej Oresic
Ph.D.

- Professor,
- Senior Research Fellow,
- University Research Fellow
- Senior Researcher
Turku Bioscience Centre (Independent units)
- ,
InFLAMES Flagship (Faculty of Medicine)

matej.oresic@utu.fi

+358 29 450 3798

+358 46 923 3395

Tykistökatu 6

Turku

: https://orcid.org/0000-0002-2856-9165

Systems Medicine group

Google Scholar

Systems biology, exposome, bioinformatics, metabolomics, lipidomics, biophysics, systems medicine, computational biology

Professor Matej Orešič holds a PhD in biophysics from Cornell University (1999; Ithaca, NY, USA). He is professor of medicine, with specialization in systems medicine at Örebro University (Sweden) and a professor of biochemistry (metabolomics) at the University of Turku (Finland). Prof. Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. As of 2016, he was made a Lifetime Honorary Fellow of the Metabolomics Society. Professor Orešič currently serves as member of the Board of Directors of the Metabolomics Society and is one of the founders of the Nordic Metabolomics Society, previously serving as its chair of the board. In 2019, he co-chaired the 1st Gordon Research Conference on ‘Metabolomics and Human Health’ (Ventura, CA, USA). Previously, he also chaired the Keystone Symposium on Systems Biology of Lipid Metabolism (2015; Breckenridge, CO, USA). Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.

Professor Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.

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Serum metabolite profile associates with the development of metabolic co-morbidities in first-episode psychosis (2016)
- Translational Psychiatry
Suvitaival T, Mantere O, Kiesepp T, Mattila I, Poho P, Hyotylainen T, Suvisaari J, Oresic M
The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes (vol 17, pg 260, 2015) (2016)
- Cell Host and Microbe
Kostic AD, Gevers D, Siljander H, Vatanen T, Hyotylainen T, Hamalainen AM, Peet A, Tillmann V, Poho P, Mattila I, Lahdesmaki H, Franzosa EA, Vaarala O, de Goffau M, Harmsen H, Ilonen J, Virtanen SM, Clish CB, Oresic M, Huttenhower C, Knip M, Xavier RJ
The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans (2016)
- Journal of Hepatology
Luukkonen PK, Zhou Y, Hyotylainen T, Leivonen M, Arola J, Orho-Melander M, Oresic M, Yki-Jarvinen H
Altered lipid metabolism preceding onset of islet autoimmunity and type 1 diabetes (2015)
- Diabetologia
Marinkovic T, Hyotylainen T, Mattila I, Poho P, Knip M, Oresic M
Analytical Lipidomics in Metabolic and Clinical Research (2015)
- Trends in Endocrinology and Metabolism
Hyotylainen T, Oresic M
Bioactive lipids dissociate steatosis and insulin resistance in the human liver in non-alcoholic fatty liver disease (2015)
- Diabetologia
Luukkonen P, Zhou Y, Sadevirta S, Leivonen M, Arola J, Oresic M, Hyotylainen T, Yki-Jarvinen H
Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2 (2015)
- Journal of Hepatology
Zhou Y, Llaurado G, Oresic M, Hyotylainen T, Orho-Melander M, Yki-Jarvinen H
COordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access (2015)
- Metabolomics
Reza M. Salek, Steffen Neumann, Daniel Schober, Jan Hummel, Kenny Billiau, Joachim Kopka, Elon Correa, Theo Reijmers, Antonio Rosato, Leonardo Tenori, Paola Turano, Silvia Marin, Catherine Deborde, Daniel Jacob, Dominique Rolin, Benjamin Dartigues, Pablo Conesa, Kenneth Haug, Philippe Rocca-Serra, Steve O’Hagan, Jie Hao, Michael van Vliet, Marko Sysi-Aho, Christian Ludwig, Jildau Bouwman, Marta Cascante, Timothy Ebbels, Julian L. Griffin, Annick Moing, Macha Nikolski, Matej Oresic, Susanna-Assunta Sansone, Mark R. Viant, Royston Goodacre, Ulrich L. Günther, Thomas Hankemeier, Claudio Luchinat, Dirk Walther, Christoph Steinbeck
Erratum to: Coordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access (vol 11, pg 1587, 2015) (2015)
- Metabolomics
Reza M. Salek, Steffen Neumann, Daniel Schober, Jan Hummel, Kenny Billiau, Joachim Kopka, Elon Correa, Theo Reijmers, Antonio Rosato, Leonardo Tenori, Paola Turano, Silvia Marin, Catherine Deborde, Daniel Jacob, Dominique Rolin, Benjamin Dartigues, Pablo Conesa, Kenneth Haug, Philippe Rocca-Serra, Steve O’Hagan, Jie Hao, Michael van Vliet, Marko Sysi-Aho, Christian Ludwig, Jildau Bouwman, Marta Cascante, Timothy Ebbels, Julian L. Griffin, Annick Moing, Macha Nikolski, Matej Oresic, Susanna-Assunta Sansone, Mark R. Viant, Royston Goodacre, Ulrich L. Günther, Thomas Hankemeier, Claudio Luchinat, Dirk Walther, Christoph Steinbeck
Increased Dihydroceramide/Ceramide Ratio Mediated by Defective Expression of degs1 Impairs Adipocyte Differentiation and Function (2015)
- Diabetes
Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A, Relat J, Cuadrado I, Pellegrinelli V, Medina-Gomez G, Lopez-Pedrera C, Tinahones FJ, Symons JD, Summers SA, Oresic M, Vidal-Puig A
Optimizing the lipidomics workflow for clinical studies-practical considerations (2015)
- Analytical and Bioanalytical Chemistry
Hyötyläinen T, Oresic M
Roux-en-Y Gastric Bypass Surgery Induces Early Plasma Metabolomic and Lipidomic Alterations in Humans Associated with Diabetes Remission (2015)
- PLoS ONE
Tulika Arora , Vidya Velagapudi , Dimitri J. Pournaras, Richard Welbourn, Carel W. le Roux, Matej Orešič, Fredrik Bäckhed
Self-organization and missing values in SOM and GTM (2015)
- Neurocomputing
T. Vatanen, M. Osmala, T. Raiko, K. Lagus, M. Sysi-Aho, M. Orešič, T. Honkela, H. Lähdesmäki
Serum Lipid and Serum Metabolite Components in relation to anthropometric parameters in EPIC-Potsdam participants (2015)
- Metabolism
Jana Foerster, Tuulia Hyötyläinen, Matej Oresic, Heli Nygren, Heiner Boeing
The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes (2015)
- Cell Host and Microbe
Kostic AD, Gevers D, Siljander H, Vatanen T, Hyotylainen T, Hamalainen AM, Peet A, Tillmann V, Poho P, Mattila I, Lahdesmaki H, Franzosa EA, Vaarala O, de Goffau M, Harmsen H, Ilonen J, Virtanen SM, Clish CB, Oresic M, Huttenhower C, Knip M, Xavier RJ
The effect of atorvastatin treatment on serum oxysterol concentrations and cytochrome P450 3A4 activity (2015)
- British Journal of Clinical Pharmacology
Hukkanen J, Puurunen J, Hyotylainen T, Savolainen MJ, Ruokonen A, Morin-Papunen L, Oresic M, Piltonen T, Tapanainen JS
The influence of sample collection methodology and sample preprocessing on the blood metabolic profile (2015)
- Bioanalysis
Jorgenrud B, Jantti S, Mattila I, Poho P, Ronningen KS, Yki-Jarvinen H, Oresic M, Hyotylainen T
The Metabolome in Finnish Carriers of the MYBPC3-Q1061X Mutation for Hypertrophic Cardiomyopathy (2015)
- PLoS ONE
Benedicte Jørgenrud, Mikko Jalanko, Tiina Heliö, Pertti Jääskeläinen, Mika Laine, Mika Hilvo, Markku S. Nieminen, Markku Laakso, Tuulia Hyötyläinen, Matej Orešič, Johanna Kuusisto
Circulating Triacylglycerol Signatures in Nonalcoholic Fatty Liver Disease Associated With the I148M Variant in PNPLA3 and With Obesity (2014)
- Diabetes
Hyysalo J, Gopalacharyulu P, Bian H, Hyotylainen T, Leivonen M, Jaser N, Juuti A, Honka MJ, Nuutila P, Olkkonen VM, Oresic M, Yki-Jarvinen H
Systems biology strategies to study lipidomes in health and disease (2014)
- Progress in Lipid Research
Hyotylainen T, Oresic M