Matej Oresic
 Ph.D.


matej.oresic@utu.fi

+358 29 450 3798

+358 46 923 3395

Tykistökatu 6

Turku


ORCID-tunnistehttps://orcid.org/0000-0002-2856-9165

Systems Medicine group

Google Scholar



Asiantuntijuusalueet
Systems biology, exposome, bioinformatics, metabolomics, lipidomics, biophysics, systems medicine, computational biology

Biografia

Professor Matej Orešič holds a PhD in biophysics from Cornell University (1999; Ithaca, NY, USA). He is professor of medicine, with specialization in systems medicine at Örebro University (Sweden) and a professor of biochemistry (metabolomics) at the University of Turku (Finland). Prof. Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. As of 2016, he was made a Lifetime Honorary Fellow of the Metabolomics Society. Professor Orešič currently serves as member of the Board of Directors of the Metabolomics Society and is one of the founders of the Nordic Metabolomics Society, previously serving as its chair of the board. In 2019, he co-chaired the 1st Gordon Research Conference on ‘Metabolomics and Human Health’ (Ventura, CA, USA). Previously, he also chaired the Keystone Symposium on Systems Biology of Lipid Metabolism (2015; Breckenridge, CO, USA). Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.



Tutkimus

Professor Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.



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  • Metabolic effects and biotransformation of perfluorohexyloctane in human hepatocytes  (2026)  
    • Environment International
     Alijagic, Andi; Chaker, Jade; Barbosa, João Marcos G.; Duberg, Daniel; Castro-Alves, Victor; Dickens, Alex M.; Orešič, Matej; Hyötyläinen, Tuulia
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity  (2026)  
    • Nature Communications
     Lamichhane, Santosh; Dickens, Alex M.; Buchacher, Tanja; Lou, Tianai; Charron-Lamoureux, Vincent; Kattelus, Roosa; Karmacharya, Pragya; Pinto da Silva, Lucas; Kråkström, Matilda; Rasool, Omid; Sen, Partho; Walker, Corinn; Patan, Abubaker; Gentry, Emily C.; Zuffa, Simone; Arzoomand, Aron; Lakshmikanth, Tadepally; Mikeš, Jaromir; Mebrahtu, Aman; Vatanen, Tommi; Raffatellu, Manuela; Zengler, Karsten; Hyötyläinen, Tuulia; Xavier, Ramnik J.; Brodin, Petter; Lahesmaa, Riitta; Dorrestein, Pieter C.; Knip, Mikael; Orešič, Matej
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Outcomes and future activities of the ‘Pan-European network in Lipidomics and EpiLipidomics – EpiLipidNET’  (2026)  
    • Metabolomics
     Kuligowski, Julia; Bertrand-Michel, Justine; Cazenave-Gassiot, Amaury; Goracci, Laura; Domingues, Pedro; Orešič, Matej; Thorsteinsdottir, Margret; Gruber, Florian; Willighagen, Egon L.; Spickett, Corinne M.; Ruskovska, Tatjana; O’Donnell, Valerie B.; Prabutzki, Patricia; Petrović, Snježana; Godzien, Joanna; Tortorella, Sara; Reis, Ana; Dias, Irundika H. K.; Schleyer, Guy; Domingues, Rosário; Fedorova, Maria
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Perfluorohexyloctane: More than Meets the Eye?  (2026)  
    • Chemical Research in Toxicology
     Alijagic, Andi; Oresic, Matej; Hyötyläinen, Tuulia
    (
    B1 Vertaisarvioitu muu artikkeli (esim. pääkirjoitus, letter, comment) tieteellisessä lehdessä)


  • Prenatal exposure to persistent organic pollutants modulates the metabolism and gut microbiota of the offspring  (2026)  
    • Environment International
     Lamichhane, Santosh; Salihovic, Samira; Sinioja, Tim; Virtanen, Suvi M.; Vatanen, Tommi; Orešič, Matej; Knip, Mikael; Hyötyläinen, Tuulia
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Progressive fibrosis in human MASLD is associated with spatially linked transcriptomic signatures of metabolic reprogramming and senescence  (2026)  
    • JHEP Reports
     Vu, Hani; Sun, Yuliangzi; Xiong, Zherui; Tan, Xiao; Radford-Smith, Daniel; Causer, Andrew; Dickens, Alex M.; Hyötyläinen, Tuulia; Evstafev, Ilia; Oresic, Matej; Nefzger, Christian; O’Sullivan, Eoin D.; Watt, Matthew J.; Ramm, Grant A.; Clouston, Andrew; Irvine, Katharine M.; Nguyen, Quan H.; Powell, Elizabeth E.
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • The inflammatory path toward type 1 diabetes begins during pregnancy  (2026)  
    • Nature Communications
     Ahrens, Angelica P.; Dias, Raquel; Hyötyläinen, Tuulia; Orešič, Matej; Triplett, Eric W.; Ludvigsson, Johnny
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Does cannabidiol reduce the adverse effects of cannabis in schizophrenia? A randomised, double-blind, cross-over trial  (2025)  
    • Neuropsychopharmacology
     Chesney, Edward; Oliver, Dominic; Sarma, Ananya; Lamper, Ayse Doga; Slimani, Ikram; Lloyd, Millie; Dickens, Alex M.; Welds, Michael; Kråkström, Matilda; Gasparini-Andre, Irma; Oresic, Matej; Lawn, Will; Babayeva, Natavan; Freeman, Tom P.; Englund, Amir; Strang, John; McGuire, Philip
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Dynamics of gut metabolome and microbiota maturation during early life  (2025)  
    • iScience
     Aatsinki, Anna-Katariina; Lamichhane, Santosh; Isokääntä, Heidi; Sen, Partho; Kråkström, Matilda; Amaral Alves, Marina; Keskitalo, Anniina; Munukka, Eveliina; Karlsson, Hasse; Perasto, Laura; Lukkarinen, Minna; Oresic, Matej; Kailanto, Henna-Maria; Karlsson, Linnea; Lahti, Leo; Dickens, Alex M.
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Intra- and inter-individual variation of the human lipidome  (2025)  
    • Trends in Analytical Chemistry
     Anh, Nguyen Hoang; Beyene, Habtamu B.; Mocciaro, Gabriele; Hahnefeld, Lisa; Lamichhane, Santosh; Fabritius, Mikael; Avela, Henri; Wang, Yuqin; Dickens, Alex M.; Gurke, Robert; Yang, Baoru; Griffiths, William J.; Hyötyläinen, Tuulia; Meikle, Peter J.; Orešič, Matej
    (
    A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä)


  • Liquid and gas-chromatography-mass spectrometry methods for exposome analysis  (2025)  
    • Journal of Chromatography A
     Castro-Alves, Victor; Nguyen, Anh Hoang; Barbosa, João Marcos G.; Orešič, Matej; Hyötyläinen, Tuulia
    (
    A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä)


  • Metabolome informs about the chemical exposome and links to brain health  (2025)  
    • Environment International
     Orešič, Matej; Karu, Naama; Zhao, Haoqi Nina; Moseley, Arthur; Hankemeier, Thomas; Wishart, David S.; Dorrestein, Pieter C.; Fiehn, Oliver; Hyötyläinen, Tuulia; Daouk, Rima Kaddurah
    (
    A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä)


  • Perfluorooctanoic acid disrupts hepatic metabolism in the developing chicken embryo  (2025)  
    • Metabolomics
     Scherbak, Nikolai; Duberg, Daniel; Kråkström, Matilda; Tikka, Pauli; Dickens, Alex M.; Engwall, Magnus; Orešič, Matej; Hyötyläinen, Tuulia
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Prenatal exposure to perfluoroalkyl substances predicts multimodal brain structural and functional outcomes in children aged 5 years: a birth cohort study  (2025)  
    • The Lancet Planetary Health
     Barron, Aaron; Dickens, Alex M; Tuulari, Jetro J; Hyötylainen, Tuulia; Kortesluoma, Susanna; Merisaari, Harri; Pulli, Elmo P; Silver, Eero; Kumpulainen, Venla; Copeland, Anni; Saukko, Ekaterina; Lewis, John D; Karlsson, Linnea; Orešič, Matej; Karlsson, Hasse
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • The SIMPLIFY Protocol: A Monophasic Extraction System Suitable for Exposomics, Metabolomics, Lipidomics, and Proteomics Research  (2025)  
    • Analytical Chemistry
     Nguyen, Anh Hoang; Castro-Alves, Victor; Holmström, Flores Emilia; Barbosa, João Marcos G.; Kråkström, Matilda; Reinivuori, Päivikki; Kauko, Otto; Dickens, Alex; Orešič, Matej; Hyötyläinen, Tuulia
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Comparative Metabolomics and Microbiome Analysis of Ethanol versus OMNImet/gene•GUT Fecal Stabilization  (2024)  
    • Analytical Chemistry
     Isokääntä, Heidi; Pinto da Silva, Lucas; Karu, Naama; Kallonen, Teemu; Aatsinki, Anna-Katariina; Hankemeier, Thomas; Schimmel, Leyla; Diaz, Edgar; Hyötyläinen, Tuulia; Dorrestein, Pieter C.; Knight, Rob; Orešič, Matej; Kaddurah-Daouk, Rima; Dickens, Alex M.; Lamichhane, Santosh
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards  (2024)  
    • Nature Communications
     Torta, Federico; Hoffmann, Nils; Burla, Bo; Alecu, Irina; Arita, Makoto; Bamba, Takeshi; Bennett, Steffany A. L.; Bertrand-Michel, Justine; Brügger, Britta; Cala, Mónica P.; Camacho-Muñoz, Dolores; Checa, Antonio; Chen, Michael; Chocholoušková, Michaela; Cinel, Michelle; Chu-Van, Emeline; Colsch, Benoit; Coman, Cristina; Connell, Lisa; Sousa Bebiana C.; Dickens, Alex M.; Fedorova, Maria; Eiríksson, Finnur Freyr; Gallart-Ayala, Hector; Ghorasaini, Mohan; Giera, Martin; Guan, Xue Li; Haid, Mark; Hankemeier, Thomas; Harms, Amy; Höring, Marcus; Holčapek, Michal; Hornemann, Thorsten; Hu, Chunxiu; Hülsmeier, Andreas J.; Huynh, Kevin; Jones, Christina M.; Ivanisevic, Julijana; Izumi, Yoshihiro; Köfeler, Harald C.; Lam, Sin Man; Lange, Mike; Lee, Jong Cheol; Liebisch, Gerhard; Lippa, Katrice; Lopez-Clavijo, Andrea F.; Manzi, Malena; Martinefski, Manuela R.; Math, Raviswamy G. H.; Mayor, Satyajit; Meikle, Peter J.; Monge, María Eugenia; Moon, Myeong Hee; Muralidharan, Sneha; Nicolaou, Anna; Nguyen-Tran, Thao; O’Donnell, Valerie B.; Orešič, Matej; Ramanathan, Arvind; Riols, Fabien; Saigusa, Daisuke; Schock, Tracey B.; Schwartz-Zimmermann, Heidi; Shui, Guanghou; Singh, Madhulika; Takahashi, Masatomo; Thorsteinsdóttir, Margrét; Tomiyasu, Noriyuki; Tournadre, Anthony; Tsugawa, Hiroshi; Tyrrell, Victoria J.; van der Gugten, Grace; Wakelam, Michael O.; Wheelock, Craig E.; Wolrab, Denise; Xu, Guowang; Xu, Tianrun; Bowden, John A.; Ekroos, Kim; Ahrends, Robert; Wenk, Markus R.
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity  (2024)  
    • Environment International
     Sen, Partho; Fan, Yong; Schlezinger, Jennifer J.; Ehrlich, Stanislav D.; Webster, Thomas F.; Hyötyläinen, Tuulia; Pedersen, Oluf; Orešič, Matej
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )


  • Hepatic glucose production is increased in MASH with significant fibrosis even in absence of diabetes  (2024)  
    • Diabetologia
     Sabatini, S.; Sen, P.; Carli, F.; Pezzica, S.; Lembo, E.; Rosso, C.; Daly, A.; Cockel, S.; Govaere, O.; Hyotylainen, T.; Mingrone, G.; Bugianesi, E.; Anstee, Q. M.; Oresic, M.; Gastaldelli, A.
    (
    Abstrakti)


  • Hepatic glucose production rises with the histological severity of metabolic dysfunction-associated steatohepatitis  (2024)  
    • Cell Reports Medicine
     Sabatini, Silvia; Sen, Partho; Carli, Fabrizia; Pezzica, Samantha; Rosso, Chiara; Lembo, Erminia; Verrastro, Ornella; Daly, Ann; Govaere, Olivier; Cockell, Simon; Hyötyläinen, Tuulia; Mingrone, Geltrude; Bugianesi, Elisabetta; Anstee, Quentin M.; Orešič, Matej; Gastaldelli, Amalia
    (
    A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )



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