Matej Oresic
Ph.D.
Systems biology, exposome, bioinformatics, metabolomics, lipidomics, biophysics, systems medicine, computational biology
Professor Matej Orešič holds a PhD in biophysics from Cornell University (1999; Ithaca, NY, USA). He is professor of medicine, with specialization in systems medicine at Örebro University (Sweden) and a professor of biochemistry (metabolomics) at the University of Turku (Finland). Prof. Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. As of 2016, he was made a Lifetime Honorary Fellow of the Metabolomics Society. Professor Orešič currently serves as member of the Board of Directors of the Metabolomics Society and is one of the founders of the Nordic Metabolomics Society, previously serving as its chair of the board. In 2019, he co-chaired the 1st Gordon Research Conference on ‘Metabolomics and Human Health’ (Ventura, CA, USA). Previously, he also chaired the Keystone Symposium on Systems Biology of Lipid Metabolism (2015; Breckenridge, CO, USA). Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)(external)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)(external)”.
Professor Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)(external)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)(external)”.
- (2025)
- Journal of Chromatography ADiabetologia
Castro-Alves, Victor; Nguyen, Anh Hoang; Barbosa, João Marcos G.; Orešič, Matej; Hyötyläinen, Tuulia
- Comparative Metabolomics and Microbiome Analysis of Ethanol versus OMNImet/gene•GUT Fecal Stabilization (2024) Isokääntä Heidi, Pinto da Silva Lucas, Karu Naama, Kallonen Teemu, Aatsinki Anna-Katariina, Hankemeier Thomas, Schimmel Leyla, Diaz Edgar, Hyötyläinen Tuulia, Dorrestein Pieter C., Knight Rob, Orešič Matej, Kaddurah-Daouk Rima, Dickens Alex M., Lamichhane Santosh
- Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards (2024)
- Nature CommunicationsNature Communications
Torta F., Hoffmann N., Burla B., Alecu I., Arita M., Bamba T., Bennett S.A.L., Bertrand-Michel J., Brügger B., Cala M.P., Camacho-Muñoz D., Checa A., Chen M., Chocholoušková M., Cinel M., Chu-Van E., Colsch B., Coman C., Connell L., Sousa B.C., Dickens A.M., Fedorova M., Eiríksson F.F., Gallart-Ayala H., Ghorasaini M., Giera M., Guan X.L., Haid M., Hankemeier T., Harms A., Höring M., Holčapek M., Hornemann T., Hu C., Hülsmeier A.J., Huynh K., Jones C.M., Ivanisevic J., Izumi Y., Köfeler H.C., Lam S.M., Lange M., Lee J.C., Liebisch G., Lippa K., Lopez-Clavijo A.F., Manzi M., Martinefski M.R., Math R.G.H., Mayor S., Meikle P.J., Monge M.E., Moon M.H., Muralidharan S., Nicolaou A., Nguyen-Tran T., O'Donnell V.B., Orešič M., Ramanathan A., Riols F., Saigusa D., Schock T.B., Schwartz-Zimmermann H., Shui G., Singh M., Takahashi M., Thorsteinsdóttir M., Tomiyasu N., Tournadre A., Tsugawa H., Tyrrell V.J., van der Gugten G., Wakelam M.O., Wheelock C.E., Wolrab D., Xu G., Xu T., Bowden J.A., Ekroos K., Ahrends R., Wen
- 2024
- Environment International
Sen Partho, Fan Yong, Schlezinger Jennifer J., Ehrlich Stanislav D., Webster Thomas F., Hyötyläinen Tuulia, Pedersen Oluf, Orešič Matej
- Hepatic glucose production is increased in MASH with significant fibrosis even in absence of diabetes (2024) Sabatini, S.; Sen, P.; Carli, F.; Pezzica, S.; Lembo, E.; Rosso, C.; Daly, A.; Cockel, S.; Govaere, O.; Hyotylainen, T.; Mingrone, G.; Bugianesi, E.; Anstee, Q. M.; Oresic, M.; Gastaldelli, A.
- Hepatic glucose production rises with the histological severity of metabolic dysfunction-associated steatohepatitis (2024)
- Cell Reports MedicineProceedings of the National Academy of Sciences of the United States of America
Sabatini, Silvia; Sen, Partho; Carli, Fabrizia; Pezzica, Samantha; Rosso, Chiara; Lembo, Erminia; Verrastro, Ornella; Daly, Ann; Govaere, Olivier; Cockell, Simon; Hyötyläinen, Tuulia; Mingrone, Geltrude; Bugianesi, Elisabetta; Anstee, Quentin M.; Orešič, Matej; Gastaldelli, Amalia
- Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease (2024) Salihovic, Samira; Nyström, Niklas; Mathisen, Charlotte Bache-Wiig; Kruse, Robert; Olbjørn, Christine; Andersen, Svend; Noble, Alexandra J.; Dorn-Rasmussen, Maria; Bazov, Igor; Perminow, Gøri; Opheim, Randi; Detlie, Trond Espen; Huppertz-Hauss, Gert; Hedin, Charlotte R. H.; Carlson, Marie; Öhman, Lena; Magnusson, Maria K.; Keita, Åsa V.; Söderholm, Johan D.; D’Amato, Mauro; Orešič, Matej; Wewer, Vibeke; Satsangi, Jack; Lindqvist, Carl Mårten; Burisch, Johan; Uhlig, Holm H.; Repsilber, Dirk; Hyötyläinen, Tuulia; Høivik, Marte Lie; Halfvarson, Jonas
- Impact of Environmental Exposures on Human Breast Milk Lipidome in Future Immune-Mediated Diseases (2024)
- Environmental Science and Technology
Hyötyläinen Tuulia, Ghaffarzadegan Tannaz, Karthikeyan Bagavathy Shanmugam, Triplett Eric, Orešič Matej, Ludvigsson Johnny
- Infant microbes and metabolites point to childhood neurodevelopmental disorders (2024) Ahrens Angelica P., Hyötyläinen Tuulia, Petrone Joseph R., Igelström Kajsa, George Christian D., Garrett Timothy J., Orešič Matej, Triplett Eric W., Ludvigsson Johnny
- 2024
- The Lancet Planetary HealthJournal of Exposure Science and Environmental Epidemiology
Hyötyläinen Tuulia, McGlinchey Aidan, Salihovic Samira, Schubert Antonia, Douglas Alex, Hay David C, O'Shaughnessy Peter J, Iredale John P, Shaw Sophie, Fowler Paul A, Orešič Matej
- Long noncoding RNA LIRIL2R modulates FOXP3 levels and suppressive function of human CD4+ regulatory T cells by regulating IL2RA (2024) Andrabi, Syed Bilal Ahmad; Kalim, Ubaid Ullah; Palani, Senthil; Khan, Mohd Moin; Khan, Meraj Hasan; Fagersund, Jimmy; Orpana, Julius; Paulin, Niklas; Batkulwar, Kedar; Junttila, Sini; Buchacher, Tanja; Grönroos, Toni; Toikka, Lea; Ammunet, Tea; Sen, Partho; Orešič, Matej; Kumpulainen, Venla; Tuomisto, Johanna E. E.; Sinha, Rahul; Marson, Alexander; Rasool, Omid; Elo, Laura L.; Lahesmaa, Riitta
- Metabolic and phenotypic changes induced by PFAS exposure in two human hepatocyte cell models (2024)
- Environment InternationalCardiovascular Research
Alijagic, Andi; Sinisalu, Lisanna; Duberg, Daniel; Kotlyar, Oleksandr; Scherbak, Nikolai; Engwall, Magnus; Orešič, Matej; Hyötyläinen, Tuulia
- Multiplatform metabolomic interlaboratory study of a whole human stool candidate reference material from omnivore and vegan donors (2024) Cruz, Abraham Kuri; Alves, Marina Amaral; Andresson, Thorkell; Bayless, Amanda L.; Bloodsworth, Kent J.; Bowden, John A.; Bullock, Kevin; Burnet, Meagan C.; Carnevale Neto, Fausto; Choy, Angelina; Clish, Clary B.; Couvillion, Sneha P.; Cumeras, Raquel; Dailey, Lucas; Dallmann, Guido; Davis, W. Clay; Deik, Amy A.; Dickens, Alex M.; Djukovic, Danijel; Dorrestein, Pieter C.; Eder, Josie G.; Fiehn, Oliver; Flores, Roberto; Gika, Helen; Hagiwara, Kehau A.; Pham, Tuan Hai; Harynuk, James J.; Aristizabal-Henao, Juan J.; Hoyt, David W.; Jean-Francois, Focant; Krakstroem, Matilda; Kumar, Amit; Kyle, Jennifer E.; Lamichhane, Santosh; Li, Yuan; Nam, Seo Lin; Mandal, Rupasri; de la Mata, A. Paulina; Meehan, Michael J.; Meikopoulos, Thomas; Metz, Thomas O.; Mouskeftara, Thomai; Munoz, Nathalie; Gowda, G. A. Nagana; Orešic, Matej; Panitchpakdi, Morgan; Pierre-Hugues, Stefanuto; Raftery, Daniel; Rushing, Blake; Schock, Tracey; Seifried, Harold; Servetas, Stephanie; Shen, Tong; Sumner, Susan; Carrillo, Kieran S. Tarazona; Thibaut, Dejong; Trejo, Jesse B.; Van Meulebroek, Lieven; Vanhaecke, Lynn; Virgiliou, Christina; Weldon, Kelly C.; Wishart, David S.; Zhang, Lu; Zheng, Jiamin; Da Silva, Sandra
- Novel Lipid Formulation Increases Absorption of Oral Cannabidiol (CBD) (2024) Chesney, Edward; Mazibuko, Ndabezinhle; Oliver, Dominic; Minichino, Amedeo; Lamper, Ayse Doga; Chester, Lucy; Reilly, Thomas J.; Lloyd, Millie; Krakstrom, Matilda; Dickens, Alex M.; Oresic, Matej; Lynch, Eric; Stoloff, Gregory; Mehta, Mitul A.; Mcguire, Philip
- Prenatal exposure to environmental contaminants and cord serum metabolite profiles in future immune-mediated diseases (2024) Karthikeyan Bagavathy Shanmugam, Hyötyläinen Tuulia, Ghaffarzadegan Tannaz, Triplett Eric, Orešič Matej, Ludvigsson Johnny
- Reproducible mass spectrometry data processing and compound annotation in MZmine 3 (2024) Heuckeroth, Steffen; Damiani, Tito; Smirnov, Aleksandr; Mokshyna, Olena; Brungs, Corinna; Korf, Ansgar; Smith, Joshua David; Stincone, Paolo; Dreolin, Nicola; Nothias, Louis-Félix; Hyötyläinen, Tuulia; Orešič, Matej; Karst, Uwe; Dorrestein, Pieter C.; Petras, Daniel; Du, Xiuxia; van der Hooft, Justin J. J.; Schmid, Robin; Pluskal, Tomáš
- Serum lipidome associates with neuroimaging features in patients with traumatic brain injury (2024) Thomas, Ilias; Newcombe, Virginia F.J.; Dickens, Alex M.; Richter, Sophie; Posti, Jussi P.; Maas, Andrew I.R.; Tenovuo, Olli; Hyötyläinen, Tuulia; Büki, András; Menon, David K.; Orešič, Matej
- Cardiomyocyte-specific PCSK9 deficiency compromises mitochondrial bioenergetics and heart function (2023) Laudette Marion, Lindbom Malin, Arif Muhammad, Cinato Mathieu, Ruiz Mario, Doran Stephen, Miljanovic Azra, Rutberg Mikael, Andersson Linda, Klevstig Martina, Henricsson Marcus, Bergh Per-Olof, Bollano Entela, Aung Nay, Smith J.Gustav, Pilon Marc, Hyötyläinen Tuulia, Orešič Matej, Perkins Rosie, Mardinoglu Adil, Levin Malin C, Borén Jan
- CBL/CAP Is Essential for Mitochondria Respiration Complex I Assembly and Bioenergetics Efficiency in Muscle Cells (2023)
- International Journal of Molecular Sciences
Aye Cho-Cho, Hammond Dean E, Rodriguez-Cuenca Sergio, Doherty Mary K, Whitfield Phillip D, Phelan Marie M, Yang Chenjing J, Perez-Perez Rafael, Li Xiaoxin, Diaz-Ramos Angels, Peddinti Gopal, Oresic Matej, Vidal-Puig Antonio, Zorzano Antonio, Ugalde Cristina, Mora Silvia
- Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children (2023)
- Frontiers in Endocrinology
Lamichhane Santosh, Sen Partho, Dickens Alex M, Kråkström Matilda, Ilonen Jorma, Lempainen Johanna, Hyöty Heikki, Lahesmaa Riitta, Veijola Riitta, Toppari Jorma, Hyötyläinen Tuulia, Knip Mikael, Orešič Matej