Genomic, Transcriptomic, and Lipidomic Profiling Highlights the Role of Inflammation in Individuals With Low High-density Lipoprotein Cholesterol



: Laurila PP, Surakka I, Sarin AP, Yetukuri L, Hyotylainen T, Soderlund S, Naukkarinen J, Tang J, Kettunen J, Mirel DB, Soronen J, Lehtimaki T, Ruokonen A, Ehnholm C, Eriksson JG, Salomaa V, Jula A, Raitakari OT, Jarvelin MR, Palotie A, Peltonen L, Oresic M, Jauhiainen M, Taskinen MR, Ripatti S

Publisher: LIPPINCOTT WILLIAMS & WILKINS

: 2013

: Arteriosclerosis, Thrombosis, and Vascular Biology

: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

: ARTERIOSCL THROM VAS

: 33

: 4

: 847

: 857

: 39

: 1079-5642

DOI: https://doi.org/10.1161/ATVBAHA.112.300733


Conclusions-Our study highlights the role of inflammation with a genetic component in subjects with low HDL-C and identifies novel cis-expression quantitative trait loci (cis-eQTL) variants in HLA region to be associated with low HDL-C. (Arterioscler Thromb Vasc Biol. 2013;33:847-857.)



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