Matej Oresic
 Ph.D.


matej.oresic@utu.fi

+358 29 450 3798

+358 46 923 3395

Tykistökatu 6

Turku


ORCID identifierhttps://orcid.org/0000-0002-2856-9165

Systems Medicine group

Google Scholar



Areas of expertise
Systems biology, exposome, bioinformatics, metabolomics, lipidomics, biophysics, systems medicine, computational biology

Biography

Professor Matej Orešič holds a PhD in biophysics from Cornell University (1999; Ithaca, NY, USA). He is professor of medicine, with specialization in systems medicine at Örebro University (Sweden) and a professor of biochemistry (metabolomics) at the University of Turku (Finland). Prof. Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. As of 2016, he was made a Lifetime Honorary Fellow of the Metabolomics Society. Professor Orešič currently serves as member of the Board of Directors of the Metabolomics Society and is one of the founders of the Nordic Metabolomics Society, previously serving as its chair of the board. In 2019, he co-chaired the 1st Gordon Research Conference on ‘Metabolomics and Human Health’ (Ventura, CA, USA). Previously, he also chaired the Keystone Symposium on Systems Biology of Lipid Metabolism (2015; Breckenridge, CO, USA). Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.



Research

Professor Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.



Publications
  
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  • Liquid and gas-chromatography-mass spectrometry methods for exposome analysis  (2025)  
    • Journal of Chromatography A
     Castro-Alves, Victor; Nguyen, Anh Hoang; Barbosa, João Marcos G.; Orešič, Matej; Hyötyläinen, Tuulia
    (
    A2 Refereed review article in a scientific journal )


  • Comparative Metabolomics and Microbiome Analysis of Ethanol versus OMNImet/gene•GUT Fecal Stabilization  (2024)  
    • Analytical Chemistry
     Isokääntä Heidi, Pinto da Silva Lucas, Karu Naama, Kallonen Teemu, Aatsinki Anna-Katariina, Hankemeier Thomas, Schimmel Leyla, Diaz Edgar, Hyötyläinen Tuulia, Dorrestein Pieter C., Knight Rob, Orešič Matej, Kaddurah-Daouk Rima, Dickens Alex M., Lamichhane Santosh
    (
    A1 Refereed original research article in a scientific journal)


  • Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards  (2024)  
    • Nature Communications
     Torta F., Hoffmann N., Burla B., Alecu I., Arita M., Bamba T., Bennett S.A.L., Bertrand-Michel J., Brügger B., Cala M.P., Camacho-Muñoz D., Checa A., Chen M., Chocholoušková M., Cinel M., Chu-Van E., Colsch B., Coman C., Connell L., Sousa B.C., Dickens A.M., Fedorova M., Eiríksson F.F., Gallart-Ayala H., Ghorasaini M., Giera M., Guan X.L., Haid M., Hankemeier T., Harms A., Höring M., Holčapek M., Hornemann T., Hu C., Hülsmeier A.J., Huynh K., Jones C.M., Ivanisevic J., Izumi Y., Köfeler H.C., Lam S.M., Lange M., Lee J.C., Liebisch G., Lippa K., Lopez-Clavijo A.F., Manzi M., Martinefski M.R., Math R.G.H., Mayor S., Meikle P.J., Monge M.E., Moon M.H., Muralidharan S., Nicolaou A., Nguyen-Tran T., O'Donnell V.B., Orešič M., Ramanathan A., Riols F., Saigusa D., Schock T.B., Schwartz-Zimmermann H., Shui G., Singh M., Takahashi M., Thorsteinsdóttir M., Tomiyasu N., Tournadre A., Tsugawa H., Tyrrell V.J., van der Gugten G., Wakelam M.O., Wheelock C.E., Wolrab D., Xu G., Xu T., Bowden J.A., Ekroos K., Ahrends R., Wen
    (
    A1 Refereed original research article in a scientific journal)


  • Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity  (2024)  
    • Environment International
     Sen Partho, Fan Yong, Schlezinger Jennifer J., Ehrlich Stanislav D., Webster Thomas F., Hyötyläinen Tuulia, Pedersen Oluf, Orešič Matej
    (
    A1 Refereed original research article in a scientific journal)


  • Hepatic glucose production rises with the histological severity of metabolic dysfunction-associated steatohepatitis  (2024)  
    • Cell Reports Medicine
     Sabatini, Silvia; Sen, Partho; Carli, Fabrizia; Pezzica, Samantha; Rosso, Chiara; Lembo, Erminia; Verrastro, Ornella; Daly, Ann; Govaere, Olivier; Cockell, Simon; Hyötyläinen, Tuulia; Mingrone, Geltrude; Bugianesi, Elisabetta; Anstee, Quentin M.; Orešič, Matej; Gastaldelli, Amalia
    (
    A1 Refereed original research article in a scientific journal)


  • Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease  (2024)  
    • Nature Communications
     Salihovic, Samira; Nyström, Niklas; Mathisen, Charlotte Bache-Wiig; Kruse, Robert; Olbjørn, Christine; Andersen, Svend; Noble, Alexandra J.; Dorn-Rasmussen, Maria; Bazov, Igor; Perminow, Gøri; Opheim, Randi; Detlie, Trond Espen; Huppertz-Hauss, Gert; Hedin, Charlotte R. H.; Carlson, Marie; Öhman, Lena; Magnusson, Maria K.; Keita, Åsa V.; Söderholm, Johan D.; D’Amato, Mauro; Orešič, Matej; Wewer, Vibeke; Satsangi, Jack; Lindqvist, Carl Mårten; Burisch, Johan; Uhlig, Holm H.; Repsilber, Dirk; Hyötyläinen, Tuulia; Høivik, Marte Lie; Halfvarson, Jonas
    (
    A1 Refereed original research article in a scientific journal)


  • Impact of Environmental Exposures on Human Breast Milk Lipidome in Future Immune-Mediated Diseases  (2024)  
    • Environmental Science and Technology
     Hyötyläinen Tuulia, Ghaffarzadegan Tannaz, Karthikeyan Bagavathy Shanmugam, Triplett Eric, Orešič Matej, Ludvigsson Johnny
    (
    A1 Refereed original research article in a scientific journal)


  • Infant microbes and metabolites point to childhood neurodevelopmental disorders  (2024)  
    • Cell
     Ahrens Angelica P., Hyötyläinen Tuulia, Petrone Joseph R., Igelström Kajsa, George Christian D., Garrett Timothy J., Orešič Matej, Triplett Eric W., Ludvigsson Johnny
    (
    A1 Refereed original research article in a scientific journal)


  • In utero exposures to perfluoroalkyl substances and the human fetal liver metabolome in Scotland : a cross-sectional study  (2024)  
    • The Lancet Planetary Health
     Hyötyläinen Tuulia, McGlinchey Aidan, Salihovic Samira, Schubert Antonia, Douglas Alex, Hay David C, O'Shaughnessy Peter J, Iredale John P, Shaw Sophie, Fowler Paul A, Orešič Matej
    (
    A1 Refereed original research article in a scientific journal)


  • Long noncoding RNA LIRIL2R modulates FOXP3 levels and suppressive function of human CD4+ regulatory T cells by regulating IL2RA  (2024)  
    • Proceedings of the National Academy of Sciences of the United States of America
     Andrabi, Syed Bilal Ahmad; Kalim, Ubaid Ullah; Palani, Senthil; Khan, Mohd Moin; Khan, Meraj Hasan; Fagersund, Jimmy; Orpana, Julius; Paulin, Niklas; Batkulwar, Kedar; Junttila, Sini; Buchacher, Tanja; Grönroos, Toni; Toikka, Lea; Ammunet, Tea; Sen, Partho; Orešič, Matej; Kumpulainen, Venla; Tuomisto, Johanna E. E.; Sinha, Rahul; Marson, Alexander; Rasool, Omid; Elo, Laura L.; Lahesmaa, Riitta
    (
    A1 Refereed original research article in a scientific journal)


  • Metabolic and phenotypic changes induced by PFAS exposure in two human hepatocyte cell models  (2024)  
    • Environment International
     Alijagic, Andi; Sinisalu, Lisanna; Duberg, Daniel; Kotlyar, Oleksandr; Scherbak, Nikolai; Engwall, Magnus; Orešič, Matej; Hyötyläinen, Tuulia
    (
    A1 Refereed original research article in a scientific journal)


  • Multiplatform metabolomic interlaboratory study of a whole human stool candidate reference material from omnivore and vegan donors  (2024)  
    • Metabolomics
     Cruz, Abraham Kuri; Alves, Marina Amaral; Andresson, Thorkell; Bayless, Amanda L.; Bloodsworth, Kent J.; Bowden, John A.; Bullock, Kevin; Burnet, Meagan C.; Carnevale Neto, Fausto; Choy, Angelina; Clish, Clary B.; Couvillion, Sneha P.; Cumeras, Raquel; Dailey, Lucas; Dallmann, Guido; Davis, W. Clay; Deik, Amy A.; Dickens, Alex M.; Djukovic, Danijel; Dorrestein, Pieter C.; Eder, Josie G.; Fiehn, Oliver; Flores, Roberto; Gika, Helen; Hagiwara, Kehau A.; Pham, Tuan Hai; Harynuk, James J.; Aristizabal-Henao, Juan J.; Hoyt, David W.; Jean-Francois, Focant; Krakstroem, Matilda; Kumar, Amit; Kyle, Jennifer E.; Lamichhane, Santosh; Li, Yuan; Nam, Seo Lin; Mandal, Rupasri; de la Mata, A. Paulina; Meehan, Michael J.; Meikopoulos, Thomas; Metz, Thomas O.; Mouskeftara, Thomai; Munoz, Nathalie; Gowda, G. A. Nagana; Orešic, Matej; Panitchpakdi, Morgan; Pierre-Hugues, Stefanuto; Raftery, Daniel; Rushing, Blake; Schock, Tracey; Seifried, Harold; Servetas, Stephanie; Shen, Tong; Sumner, Susan; Carrillo, Kieran S. Tarazona; Thibaut, Dejong; Trejo, Jesse B.; Van Meulebroek, Lieven; Vanhaecke, Lynn; Virgiliou, Christina; Weldon, Kelly C.; Wishart, David S.; Zhang, Lu; Zheng, Jiamin; Da Silva, Sandra
    (
    A1 Refereed original research article in a scientific journal)


  • Novel Lipid Formulation Increases Absorption of Oral Cannabidiol (CBD)  (2024)  
    • Pharmaceutics
     Chesney, Edward; Mazibuko, Ndabezinhle; Oliver, Dominic; Minichino, Amedeo; Lamper, Ayse Doga; Chester, Lucy; Reilly, Thomas J.; Lloyd, Millie; Krakstrom, Matilda; Dickens, Alex M.; Oresic, Matej; Lynch, Eric; Stoloff, Gregory; Mehta, Mitul A.; Mcguire, Philip
    (
    A1 Refereed original research article in a scientific journal)


  • Prenatal exposure to environmental contaminants and cord serum metabolite profiles in future immune-mediated diseases  (2024)  
    • Journal of Exposure Science and Environmental Epidemiology
     Karthikeyan Bagavathy Shanmugam, Hyötyläinen Tuulia, Ghaffarzadegan Tannaz, Triplett Eric, Orešič Matej, Ludvigsson Johnny
    (
    A1 Refereed original research article in a scientific journal)


  • Reproducible mass spectrometry data processing and compound annotation in MZmine 3  (2024)  
    • Nature Protocols
     Heuckeroth, Steffen; Damiani, Tito; Smirnov, Aleksandr; Mokshyna, Olena; Brungs, Corinna; Korf, Ansgar; Smith, Joshua David; Stincone, Paolo; Dreolin, Nicola; Nothias, Louis-Félix; Hyötyläinen, Tuulia; Orešič, Matej; Karst, Uwe; Dorrestein, Pieter C.; Petras, Daniel; Du, Xiuxia; van der Hooft, Justin J. J.; Schmid, Robin; Pluskal, Tomáš
    (
    A1 Refereed original research article in a scientific journal)


  • Serum lipidome associates with neuroimaging features in patients with traumatic brain injury  (2024)  
    • iScience
     Thomas, Ilias; Newcombe, Virginia F.J.; Dickens, Alex M.; Richter, Sophie; Posti, Jussi P.; Maas, Andrew I.R.; Tenovuo, Olli; Hyötyläinen, Tuulia; Büki, András; Menon, David K.; Orešič, Matej
    (
    A1 Refereed original research article in a scientific journal)


  • Cardiomyocyte-specific PCSK9 deficiency compromises mitochondrial bioenergetics and heart function  (2023)  
    • Cardiovascular Research
     Laudette Marion, Lindbom Malin, Arif Muhammad, Cinato Mathieu, Ruiz Mario, Doran Stephen, Miljanovic Azra, Rutberg Mikael, Andersson Linda, Klevstig Martina, Henricsson Marcus, Bergh Per-Olof, Bollano Entela, Aung Nay, Smith J.Gustav, Pilon Marc, Hyötyläinen Tuulia, Orešič Matej, Perkins Rosie, Mardinoglu Adil, Levin Malin C, Borén Jan
    (
    A1 Refereed original research article in a scientific journal)


  • CBL/CAP Is Essential for Mitochondria Respiration Complex I Assembly and Bioenergetics Efficiency in Muscle Cells  (2023)  
    • International Journal of Molecular Sciences
     Aye Cho-Cho, Hammond Dean E, Rodriguez-Cuenca Sergio, Doherty Mary K, Whitfield Phillip D, Phelan Marie M, Yang Chenjing J, Perez-Perez Rafael, Li Xiaoxin, Diaz-Ramos Angels, Peddinti Gopal, Oresic Matej, Vidal-Puig Antonio, Zorzano Antonio, Ugalde Cristina, Mora Silvia
    (
    A1 Refereed original research article in a scientific journal)


  • Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children  (2023)  
    • Frontiers in Endocrinology
     Lamichhane Santosh, Sen Partho, Dickens Alex M, Kråkström Matilda, Ilonen Jorma, Lempainen Johanna, Hyöty Heikki, Lahesmaa Riitta, Veijola Riitta, Toppari Jorma, Hyötyläinen Tuulia, Knip Mikael, Orešič Matej

    (
    A1 Refereed original research article in a scientific journal)


  • Classification of Common Food Lipid Sources Regarding Healthiness Using Advanced Lipidomics: A Four-Arm Crossover Study  (2023)  
    • International Journal of Molecular Sciences
     Monfort-Pires Milena, Lamichhane Santosh, Alonso Cristina, Egelandsdal Bjørg, Oresic Matej, Jordahl Vilde Overrein, Skjolsvold Oda, Perez-Ruiz Irantzu, Blanco Maria Encarnación, Skeie Siv, Martins Catia, Haug Anna
    (
    A1 Refereed original research article in a scientific journal)



Last updated on 2025-11-06 at 16:19