Matej Oresic
Ph.D.
matej.oresic@utu.fi +358 29 450 3798 +358 46 923 3395 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0002-2856-9165 |
Systems biology, exposome, bioinformatics, metabolomics, lipidomics, biophysics, systems medicine, computational biology
Professor Matej Orešič holds a PhD in biophysics from Cornell University (1999; Ithaca, NY, USA). He is professor of medicine, with specialization in systems medicine at Örebro University (Sweden) and a professor of biochemistry (metabolomics) at the University of Turku (Finland). Prof. Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. As of 2016, he was made a Lifetime Honorary Fellow of the Metabolomics Society. Professor Orešič currently serves as member of the Board of Directors of the Metabolomics Society and is one of the founders of the Nordic Metabolomics Society, previously serving as its chair of the board. In 2019, he co-chaired the 1st Gordon Research Conference on ‘Metabolomics and Human Health’ (Ventura, CA, USA). Previously, he also chaired the Keystone Symposium on Systems Biology of Lipid Metabolism (2015; Breckenridge, CO, USA). Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.
Professor Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.
- Metabolic effects and biotransformation of perfluorohexyloctane in human hepatocytes (2026)
- Environment International
(A1 Refereed original research article in a scientific journal) - Microbiome-derived bile acid signatures in early life and their association with islet autoimmunity (2026)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Perfluorohexyloctane: More than Meets the Eye? (2026)
- Chemical Research in Toxicology
(B1 Other refereed article (e.g., editorial, letter, comment) in a scientific journal) - Prenatal exposure to persistent organic pollutants modulates the metabolism and gut microbiota of the offspring (2026)
- Environment International
(A1 Refereed original research article in a scientific journal) - Progressive fibrosis in human MASLD is associated with spatially linked transcriptomic signatures of metabolic reprogramming and senescence (2026)
- JHEP Reports
(A1 Refereed original research article in a scientific journal) - The inflammatory path toward type 1 diabetes begins during pregnancy (2026)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Does cannabidiol reduce the adverse effects of cannabis in schizophrenia? A randomised, double-blind, cross-over trial (2025)
- Neuropsychopharmacology
(A1 Refereed original research article in a scientific journal) - Dynamics of gut metabolome and microbiota maturation during early life (2025)
- iScience
(A1 Refereed original research article in a scientific journal) - Intra- and inter-individual variation of the human lipidome (2025)
- Trends in Analytical Chemistry
(A2 Refereed review article in a scientific journal ) - Liquid and gas-chromatography-mass spectrometry methods for exposome analysis (2025)
- Journal of Chromatography A
(A2 Refereed review article in a scientific journal ) - Metabolome informs about the chemical exposome and links to brain health (2025)
- Environment International
(A2 Refereed review article in a scientific journal ) - Perfluorooctanoic acid disrupts hepatic metabolism in the developing chicken embryo (2025)
- Metabolomics
(A1 Refereed original research article in a scientific journal) - Prenatal exposure to perfluoroalkyl substances predicts multimodal brain structural and functional outcomes in children aged 5 years: a birth cohort study (2025)
- The Lancet Planetary Health
(A1 Refereed original research article in a scientific journal) - The SIMPLIFY Protocol: A Monophasic Extraction System Suitable for Exposomics, Metabolomics, Lipidomics, and Proteomics Research (2025)
- Analytical Chemistry
(A1 Refereed original research article in a scientific journal) - Comparative Metabolomics and Microbiome Analysis of Ethanol versus OMNImet/gene•GUT Fecal Stabilization (2024)
- Analytical Chemistry
(A1 Refereed original research article in a scientific journal) - Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards (2024)
- Nature Communications
(A1 Refereed original research article in a scientific journal) - Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity (2024)
- Environment International
(A1 Refereed original research article in a scientific journal) - Hepatic glucose production is increased in MASH with significant fibrosis even in absence of diabetes (2024)
- Diabetologia
(Abstract) - Hepatic glucose production rises with the histological severity of metabolic dysfunction-associated steatohepatitis (2024)
- Cell Reports Medicine
(A1 Refereed original research article in a scientific journal) - Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease (2024)
- Nature Communications
(A1 Refereed original research article in a scientific journal)



