Matej Oresic
Ph.D.
matej.oresic@utu.fi +358 29 450 3798 +358 46 923 3395 Tykistökatu 6 Turku |
Systems biology, exposome, bioinformatics, metabolomics, lipidomics, biophysics, systems medicine, computational biology
Professor Matej Orešič holds a PhD in biophysics from Cornell University (1999; Ithaca, NY, USA). He is professor of medicine, with specialization in systems medicine at Örebro University (Sweden) and a professor of biochemistry (metabolomics) at the University of Turku (Finland). Prof. Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. As of 2016, he was made a Lifetime Honorary Fellow of the Metabolomics Society. Professor Orešič currently serves as member of the Board of Directors of the Metabolomics Society and is one of the founders of the Nordic Metabolomics Society, previously serving as its chair of the board. In 2019, he co-chaired the 1st Gordon Research Conference on ‘Metabolomics and Human Health’ (Ventura, CA, USA). Previously, he also chaired the Keystone Symposium on Systems Biology of Lipid Metabolism (2015; Breckenridge, CO, USA). Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.
Professor Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.
- The human liver lipidome is significantly related to the lipid composition and aggregation susceptibility of low-density lipoprotein (LDL) particles (2022)
- Atherosclerosis
- Traumatic brain injury: progress and challenges in prevention, clinical care, and research (2022)
- Lancet Neurology
- Umbilical cord blood DNA methylation in children who later develop type 1 diabetes (2022)
- Diabetologia
- 1‐deoxyceramides – key players in lipotoxicity and progression to type 2 diabetes? (2021)
- Acta Physiologica
- Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2-mediated mechanism (2021)
- British Journal of Pharmacology
- Allostatic hypermetabolic response in PGC1 alpha/beta heterozygote mouse despite mitochondrial defects (2021)
- FASEB Journal
- Association Between Circulating Lipids and Future Weight Gain in Individuals With an At-Risk Mental State and in First-Episode Psychosis (2021)
- Schizophrenia Bulletin
- Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species (2021)
- Scientific Reports
- Deep learning meets metabolomics: a methodological perspective (2021)
- Briefings in Bioinformatics
- Dysregulated lipid metabolism precedes onset of psychosis (2021)
- Biological Psychiatry
- Exposure to per- and polyfluoroalkyl substances associates with an altered lipid composition of breast milk (2021)
- Environment International
- Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking (2021)
- European Heart Journal
- Interpreting the lipidome: bioinformatic approaches to embrace the complexity (2021)
- Metabolomics
- Linking Gut Microbiome and Lipid Metabolism: Moving beyond Associations (2021)
- Metabolites
- Lipidomic Analyses Reveal Modulation of Lipid Metabolism by the PFAS Perfluoroundecanoic Acid (PFUnDA) in Non-Obese Diabetic Mice (2021)
- Frontiers in Genetics
- Lipidomic and Metabolomic Signature of Progression of Chronic Kidney Disease in Patients with Severe Obesity (2021)
- Metabolites
- Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests (2021)
- Nature Reviews Gastroenterology and Hepatology
- Perfluoroalkyl substances are increased in patients with late-onset ulcerative colitis and induce intestinal barrier defects ex vivo in murine intestinal tissue (2021)
- Scandinavian Journal of Gastroenterology
- Quantitative genome-scale metabolic modeling of human CD4+ T cell differentiation reveals subset-specific regulation of glycosphingolipid pathways (2021)
- Cell Reports
- Systems biology approaches to study lipidomes in health and disease (2021)
- Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids



