Matej Oresic
Ph.D.
matej.oresic@utu.fi +358 29 450 3798 +358 46 923 3395 Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0002-2856-9165 |
Systems biology, exposome, bioinformatics, metabolomics, lipidomics, biophysics, systems medicine, computational biology
Professor Matej Orešič holds a PhD in biophysics from Cornell University (1999; Ithaca, NY, USA). He is professor of medicine, with specialization in systems medicine at Örebro University (Sweden) and a professor of biochemistry (metabolomics) at the University of Turku (Finland). Prof. Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. As of 2016, he was made a Lifetime Honorary Fellow of the Metabolomics Society. Professor Orešič currently serves as member of the Board of Directors of the Metabolomics Society and is one of the founders of the Nordic Metabolomics Society, previously serving as its chair of the board. In 2019, he co-chaired the 1st Gordon Research Conference on ‘Metabolomics and Human Health’ (Ventura, CA, USA). Previously, he also chaired the Keystone Symposium on Systems Biology of Lipid Metabolism (2015; Breckenridge, CO, USA). Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.
Professor Orešič’s main research areas include exposomics and metabolomics applications in biomedical research and systems medicine. He is particularly interested in the identification of environmental exposures (exposome) and disease processes associated with different metabolic phenotypes and the underlying mechanisms linking these processes with the development of specific disorders or their co-morbidities. Prof. Orešič also initiated the popular MZmine open-source project, which led to the development and release of popular software for metabolomics data processing. Professor Orešič currently coordinates Horizon Europe project “Inflammation in human early life: targeting impacts on life-course health – INITIALISE (https://initialise-project.eu/)”. He is also Co-Coordinator of the new Horizon Europe project “Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease – EDC-MASLD (https://edc-masld.eu/)”.
- Serum lipidome associates with neuroimaging features in patients with traumatic brain injury (2024)
- iScience
(A1 Refereed original research article in a scientific journal) - Cardiomyocyte-specific PCSK9 deficiency compromises mitochondrial bioenergetics and heart function (2023)
- Cardiovascular Research
(A1 Refereed original research article in a scientific journal) - CBL/CAP Is Essential for Mitochondria Respiration Complex I Assembly and Bioenergetics Efficiency in Muscle Cells (2023)
- International Journal of Molecular Sciences
(A1 Refereed original research article in a scientific journal) - Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children (2023)
- Frontiers in Endocrinology
(A1 Refereed original research article in a scientific journal) - Classification of Common Food Lipid Sources Regarding Healthiness Using Advanced Lipidomics: A Four-Arm Crossover Study (2023)
- International Journal of Molecular Sciences
(A1 Refereed original research article in a scientific journal) - Cord serum metabolic signatures of future progression to immune-mediated diseases (2023)
- iScience
(A1 Refereed original research article in a scientific journal) - Deep learning facilitates multi-data type analysis and predictive biomarker discovery in cancer precision medicine (2023)
- Computational and Structural Biotechnology Journal
(A2 Refereed review article in a scientific journal ) - Dynamics of the Lipidome in a Colon Simulator (2023)
- Metabolites
(A1 Refereed original research article in a scientific journal) - Impact of exposure to per- and polyfluoroalkyl substances on fecal microbiota composition in mother-infant dyads (2023)
- Environment International
(A1 Refereed original research article in a scientific journal) - Integrating Omics Data in Genome-Scale Metabolic Modeling: A Methodological Perspective for Precision Medicine (2023)
- Metabolites
(A2 Refereed review article in a scientific journal ) - Integrative analysis of multimodal mass spectrometry data in MZmine 3 (2023)
- Nature Biotechnology
(B1 Non-refereed article in a scientific journal) - Recent advances towards mass spectrometry-based clinical lipidomics (2023)
- Current Opinion in Chemical Biology
(A2 Refereed review article in a scientific journal ) - Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes (2023)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - The gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and mice (2023)
- Nature Microbiology
(A1 Refereed original research article in a scientific journal) - Analysis of the SYSDIET Healthy Nordic Diet randomized trial based on metabolic profiling reveal beneficial effects on glucose metabolism and blood lipids (2022)
- Clinical Nutrition
(A1 Refereed original research article in a scientific journal) - Correction: Integration of metabolomics and expression of glycerol-3-phosphate acyltransferase (GPAM) in breast cancer-link to patient survival, hormone receptor status, and metabolic profiling (Journal of Proteome Research (2012) 11:2 (850-860) DOI: 10.1021/pr200685r) (2022)
- Journal of Proteome Research
(Other publication) - Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetes (2022)
- Cell Reports Medicine
(A1 Refereed original research article in a scientific journal) - Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on Plasma Endocannabinoid Levels in Healthy Volunteers: A Randomized Double-Blind Four-Arm Crossover Study (2022)
- Cannabis and Cannabinoid Research
(A1 Refereed original research article in a scientific journal) - Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease (2022)
- Journal of Hepatology
(A1 Refereed original research article in a scientific journal) - Exposure to persistent organic pollutants alters the serum metabolome in non-obese diabetic mice (2022)
- Metabolomics
(A1 Refereed original research article in a scientific journal)



