Kalle Rytkönen
Senior Research Fellow, InFLAMES Flagship, Institute of Biomedicine / Turku Bioscience Centre
katury@utu.fi Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0002-5138-0889 |
Areas of expertise
Female reproduction; reproductive immunology; uterus; endometrium; endometriosis; preeclampsia; hypoxia; gene regulation; functional genomics; single-cell transcriptomics
Female reproduction; reproductive immunology; uterus; endometrium; endometriosis; preeclampsia; hypoxia; gene regulation; functional genomics; single-cell transcriptomics
Biography
2011, PhD, University of Turku
2012-2015 Post Doc, Prof. Gunter Wagner lab, Yale Systems Biology Institute, Yale University
2016-2018 Marie Curie Research Fellow, Institute of Biomedicine / Turku Centre for Biotechnology
2019- Research Fellow associated with Prof. Laura Elo and Prof. Matti Poutanen groups, Turku Bioscience Centre / Institute of Biomedicine
2022- Adjunct professor, Institute of Biomedicine
Research
Current research focuses on the gene regulation of the uterine endometrium and endometrium related disorders such as preeclampsia, endometriosis, PCOS and heavy menstrual bleeding. To better understand the uterine biology and the roles of specific uterine cell types I utilize transcriptomics, steroidomics and computational biology tools.
Teaching
Lectures in courses: Modern biotechnologies and bioinformatics; Systems biology; Bioinformatics in Drug Discovery.
Publications 
1 of 2
- Disruption of HSD17B12 in mouse hepatocytes leads to reduced body weight and defect in the lipid droplet expansion associated with microvesicular steatosis (2024)
- FASEB Journal
(A1 Refereed original research article in a scientific journal) - Gene Regulatory Network Analysis of Decidual Stromal Cells and Natural Killer Cells (2024)
- Reproductive Sciences
(A1 Refereed original research article in a scientific journal) - Integrative analysis of endometriosis and adenomyosis through single-cell transcriptomics (2024)
- Human Reproduction
(Abstract) - Serum Hydroxysteroid (17beta) dehydrogenase 1 concentration in pregnant women correlates with pregnancy-associated plasma protein a but does not serve as an independent marker for preeclampsia (2024)
- Biology of Reproduction
(A1 Refereed original research article in a scientific journal) - Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia (2022)
- Reproduction
(A1 Refereed original research article in a scientific journal) - COVID-19-specific transcriptomic signature detectable in blood across multiple cohorts (2022)
- Frontiers in Genetics
(A1 Refereed original research article in a scientific journal) - Dirichlet process mixture models for single-cell RNA-seq clustering (2022)
- Biology Open
(A1 Refereed original research article in a scientific journal) - Glycolysis and Heavy Menstrual Bleeding (2022)
- Reproductive Sciences
(B1 Non-refereed article in a scientific journal) - Histone H3K4me3 breadth in hypoxia reveals endometrial core functions and stress adaptation linked to endometriosis (2022)
- iScience
(A1 Refereed original research article in a scientific journal) - Overexpression of Human Estrogen Biosynthetic Enzyme Hydroxysteroid (17beta) Dehydrogenase Type 1 Induces Adenomyosis-like Phenotype in Transgenic Mice (2022)
- International Journal of Molecular Sciences
(A1 Refereed original research article in a scientific journal) - Computational strategies for single-cell multi-omics integration (2021)
- Computational and Structural Biotechnology Journal
(A1 Refereed original research article in a scientific journal) - Differential ATAC-seq and ChIP-seq peak detection using ROTS (2021)
- NAR Genomics and Bioinformatics: Nucleic Acids Research Genomics and Bioinformatics
(A1 Refereed original research article in a scientific journal) - A relational database to identify differentially expressed genes in the endometrium and endometriosis lesions (2020)
- Scientific Data
(A1 Refereed original research article in a scientific journal) - Transcriptomic responses to hypoxia in endometrial and decidual stromal cells (2020)
- Reproduction
(A1 Refereed original research article in a scientific journal) - Decidualization of Human Endometrial Stromal Fibroblasts is a Multiphasic Process Involving Distinct Transcriptional Programs (2019)
- Reproductive Sciences
(A1 Refereed original research article in a scientific journal) - RepViz: A replicate-driven R tool for visualizing genomic regions (2019)
- BMC Research Notes
(A1 Refereed original research article in a scientific journal) - Evolution: Oxygen and early animals (2018)
- eLife
(B1 Non-refereed article in a scientific journal) - Keskenmeno on ihmisellä sääntö eikä poikkeus – kohtu valikoi tarkkaan, kenet se ottaa vastaan (2018)
- Helsingin Sanomat
(E1 Popularised article) - The evolution of early cellular systems viewed through the lens of biological interactions. (2015)
- Frontiers in Microbiology
(A2 Refereed review article in a scientific journal ) - From genomes to functions in aquatic biology (2012)
- Marine Genomics
(A1 Refereed original research article in a scientific journal)
UTU Research Portal