Kalle Rytkönen
Adjunct professor, Institute of Biomedicine / Turku Bioscience Centre
katury@utu.fi Tykistökatu 6 Turku ORCID identifier: https://orcid.org/0000-0002-5138-0889 |
Female reproduction; uterus; endometrium; endometriosis; preeclampsia; hypoxia; gene regulation; functional genomics; single-cell transcriptomics
2011, PhD, University of Turku
2012-2015 Post Doc, Prof. Gunter Wagner lab, Yale Systems Biology Institute, Yale University
2016-2018 Marie Curie Research Fellow, Institute of Biomedicine / Turku Centre for Biotechnology
2019- Research Fellow associated with Prof. Laura Elo and Prof. Matti Poutanen groups, Turku Bioscience Centre / Institute of Biomedicine
2022- Adjunct professor, Institute of Biomedicine
Current research focuses on the gene regulation of the uterine endometrium and endometrium related disorders such as preeclampsia, endometriosis and heavy menstrual bleeding. To better understand the uterine biology and the roles of specific uterine cell types I utilize transcriptomics, steroidomics and computational biology tools.
Lectures in courses: Modern biotechnologies and bioinformatics; Systems biology; Bioinformatics in Drug Discovery.
- Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia (2022)
- Reproduction
(Refereed journal article or data article (A1)) - COVID-19-specific transcriptomic signature detectable in blood across multiple cohorts (2022)
- Frontiers in Genetics
(Refereed journal article or data article (A1)) - Dirichlet process mixture models for single-cell RNA-seq clustering (2022)
- Biology Open
(Refereed journal article or data article (A1)) - Glycolysis and Heavy Menstrual Bleeding (2022)
- Reproductive Sciences
(Article or data-article in scientific journal (B1)) - Histone H3K4me3 breadth in hypoxia reveals endometrial core functions and stress adaptation linked to endometriosis (2022)
- iScience
(Refereed journal article or data article (A1)) - Overexpression of Human Estrogen Biosynthetic Enzyme Hydroxysteroid (17beta) Dehydrogenase Type 1 Induces Adenomyosis-like Phenotype in Transgenic Mice (2022)
- International Journal of Molecular Sciences
(Refereed journal article or data article (A1)) - Computational strategies for single-cell multi-omics integration (2021)
- Computational and Structural Biotechnology Journal
(Refereed journal article or data article (A1)) - Differential ATAC-seq and ChIP-seq peak detection using ROTS (2021)
- NAR Genomics and Bioinformatics: Nucleic Acids Research Genomics and Bioinformatics
(Refereed journal article or data article (A1)) - A relational database to identify differentially expressed genes in the endometrium and endometriosis lesions (2020)
- Scientific Data
(Refereed journal article or data article (A1)) - Transcriptomic responses to hypoxia in endometrial and decidual stromal cells (2020)
- Reproduction
(Refereed journal article or data article (A1)) - Decidualization of Human Endometrial Stromal Fibroblasts is a Multiphasic Process Involving Distinct Transcriptional Programs (2019)
- Reproductive Sciences
(Refereed journal article or data article (A1)) - RepViz: A replicate-driven R tool for visualizing genomic regions (2019)
- BMC Research Notes
(Refereed journal article or data article (A1)) - Evolution: Oxygen and early animals (2018)
- eLife
(Article or data-article in scientific journal (B1)) - Keskenmeno on ihmisellä sääntö eikä poikkeus – kohtu valikoi tarkkaan, kenet se ottaa vastaan (2018)
- Helsingin Sanomat
(Popularised article or blog post (E1)) - The evolution of early cellular systems viewed through the lens of biological interactions. (2015)
- Frontiers in Microbiology
(Refereed review article in scientific journal (A2)) - From genomes to functions in aquatic biology (2012)
- Marine Genomics
(Refereed journal article or data article (A1)) - Transcriptional responses to hypoxia are enhanced by recurrent hypoxia (hypoxic preconditioning) in the epaulette shark (2012)
- Physiological Genomics
(Refereed journal article or data article (A1)) - Evolutionary origins of oxygen sensing in animals (2011)
- EMBO Reports
(Refereed review article in scientific journal (A2)) - Functional genomics in aquatic toxicology-Do not forget the function (2011)
- Aquatic Toxicology
(Refereed review article in scientific journal (A2)) - Molecular Evolution of the Metazoan PHD-HIF Oxygen-Sensing System (2011)
- Molecular Biology and Evolution
(Refereed journal article or data article (A1))