A1 Refereed original research article in a scientific journal
COVID-19-specific transcriptomic signature detectable in blood across multiple cohorts
Authors: Välikangas Tommi, Junttila Sini, Rytkönen Kalle T, Kukkonen-Macchi Anu, Suomi Tomi, Elo Laura L
Publisher: FRONTIERS MEDIA SA
Publication year: 2022
Journal: Frontiers in Genetics
Journal name in source: FRONTIERS IN GENETICS
Journal acronym: FRONT GENET
Article number: 929887
Volume: 13
Number of pages: 17
eISSN: 1664-8021
DOI: https://doi.org/10.3389/fgene.2022.929887
Web address : https://doi.org/10.3389/fgene.2022.929887
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/176228286
The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading across the world despite vast global vaccination efforts. Consequently, many studies have looked for potential human host factors and immune mechanisms associated with the disease. However, most studies have focused on comparing COVID-19 patients to healthy controls, while fewer have elucidated the specific host factors distinguishing COVID-19 from other infections. To discover genes specifically related to COVID-19, we reanalyzed transcriptome data from nine independent cohort studies, covering multiple infections, including COVID-19, influenza, seasonal coronaviruses, and bacterial pneumonia. The identified COVID-19-specific signature consisted of 149 genes, involving many signals previously associated with the disease, such as induction of a strong immunoglobulin response and hemostasis, as well as dysregulation of cell cycle-related processes. Additionally, potential new gene candidates related to COVID-19 were discovered. To facilitate exploration of the signature with respect to disease severity, disease progression, and different cell types, we also offer an online tool for easy visualization of the selected genes across multiple datasets at both bulk and single-cell levels.
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