A1 Refereed original research article in a scientific journal

Cell type markers indicate distinct contributions of decidual stromal cells and natural killer cells in preeclampsia



Authors: Rytkönen Kalle T, Adossa Nigatu, Mahmoudian Mehrad, Lönnberg Tapio, Poutanen Matti, Elo Laura L

Publisher: BIOSCIENTIFICA LTD

Publication year: 2022

Journal: Reproduction

Journal name in source: REPRODUCTION

Journal acronym: REPRODUCTION

Volume: 164

Issue: 5

First page : V9

Last page: V13

Number of pages: 5

ISSN: 1470-1626

eISSN: 1741-7899

DOI: https://doi.org/10.1530/REP-22-0079

Web address : http://dx.doi.org/10.1530%2FREP-22-0079

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/178040409


Abstract
In brief: Preeclampsia is a common serious disorder that can occur during pregnancy. This study uses integrative analysis of preeclampsia transcriptomes and single-cell transcriptomes to predict cell type-specific contributions to preeclampsia. Preeclampsia is a devastating pregnancy disorder and a major cause of maternal and perinatal mortality. By combining previous transcriptomic results on preeclampsia with single-cell sequencing data, we here predict distinct and partly unanticipated contributions of decidual stromal cells and uterine natural killer cells in early- and late-onset preeclampsia.

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Last updated on 2024-26-11 at 18:24