Janne Leivo
Ph.D.
jpleiv@utu.fi Kiinamyllynkatu 10 Turku Office: D6048 ORCID identifier: https://orcid.org/0000-0002-1032-6667 |
Antibody engineering; Immunoassays; Extracellular vesicles; Diagnostics
I am a senior researcher fellow and InFLAMES Group leader at the Department of Life Technologies and FICAN West Cancer Centre. My group bridges novel biomarker concepts, extracellular vesicle analytics, and advanced immunoassay technologies to enable more sensitive and specific diagnostics.
The primary focus of our group is to design and validate novel biomarker concepts for early cancer detection and precision disease management. We have established a biomarker development pipeline based on glycovariants of various tumor markers and extracellular vesicles.
Our research is in the interface of basic and translational research, combining biomarker discovery, antibody and assay development, and clinical validation to address the clinical need for the detection of the most common solid cancers.
- Development of recombinant antibody-based enzyme-linked immunosorbent assay (ELISA) for the detection of skatole (2016)
- Analytical Biochemistry
(A1 Refereed original research article in a scientific journal) - Role of lectin microarrays in cancer diagnosis (2016)
- Proteomics
(A2 Refereed review article in a scientific journal ) - Immuno-based detection of extracellular vesicles in urine as diagnostic marker for prostate cancer (2015)
- International Journal of Cancer
(A1 Refereed original research article in a scientific journal) - Multiresidue Detection of Fluoroquinolones: Specificity Engineering of a Recombinant Antibody with Oligonucleotide-Directed Mutagenesis (2013)
- Journal of Agricultural and Food Chemistry
(A1 Refereed original research article in a scientific journal) - Directed antibody-engineering techniques and their applications in food immunoassays (2011)
- Trends in Analytical Chemistry
(A1 Refereed original research article in a scientific journal) - Engineering of a broad-specificity antibody: Detection of eight fluoroquinolone antibiotics simultaneously (2011)
- Analytical Biochemistry
(A1 Refereed original research article in a scientific journal) - Synthetic single-framework antibody library integrated with rapid affinity maturation by V-L shuffling (2011)
- Protein Engineering, Design and Selection
(A1 Refereed original research article in a scientific journal) - Development of an optical surface plasmon resonance biosensor assay for (fluoro)quinolones in egg, fish, and poultry meat (2008)
- Analytica Chimica Acta
(A1 Refereed original research article in a scientific journal)
