A1 Refereed original research article in a scientific journal
Immuno-based detection of extracellular vesicles in urine as diagnostic marker for prostate cancer
Authors: Diederick Duijvesz, C. Yin L. Versluis,†, Christa A.M. van der Fels, Mirella S. Vredenbregt-van den Berg, Janne Leivo, Mari T. Peltola, Chris H. Bangma, Kim S.I. Pettersson, Guido Jenster
Publisher: WILEY-BLACKWELL
Publication year: 2015
Journal: International Journal of Cancer
Journal name in source: INTERNATIONAL JOURNAL OF CANCER
Journal acronym: INT J CANCER
Volume: 137
Issue: 12
First page : 2869
Last page: 2878
Number of pages: 10
ISSN: 0020-7136
DOI: https://doi.org/10.1002/ijc.29664
What's new? The vesicles cast off by cancer cells could serve as billboards advertising the cancer's presence - if we knew how to read them. Detecting markers in prostate cancer vesicles is currently labor intensive. These authors set out to change that, by developing an immunoaffinity technique to expose these cellular markers more easily. Using the assay, they detected two cell surface proteins, CD9 and CD63, in the urine of men who had prostate cancer. They found far less of the markers in men without cancer, men without prostates, and women, suggesting CD9 and CD63 could be useful prostate cancer markers.
