Janne Leivo
Ph.D., adj. prof.
jpleiv@utu.fi Kiinamyllynkatu 10 Turku Office: D6048 ORCID identifier: https://orcid.org/0000-0002-1032-6667 |
Areas of expertise
Antibody engineering; Immunoassays; Extracellular vesicles; Exosomes; Prostate cancer
Antibody engineering; Immunoassays; Extracellular vesicles; Exosomes; Prostate cancer
Research community or research topic
MSCA-ITN proEVLifecycle (https://proevlifecycle.eu/)
MSCA-ITN proEVLifecycle (https://proevlifecycle.eu/)
Research
The primary focus of our group is to design and validate novel biomarker concepts for early cancer detection and precision disease management. We have established a biomarker development pipeline based on glycovariants of various tumor markers and extracellular vesicles.
Our research is in the interface of basic and translational research, combining biomarker discovery, antibody and assay development and clinical validation to address the clinical need for the detection of most common solid cancers.
Publications
- Designing nanoparticle-based bioaffinity assays for the detection of extracellular vesicles (2025)
- Nanomedicine
(B1 Other refereed article (e.g., editorial, letter, comment) in a scientific journal) - Evaluation of Integrin Glycovariants as Biomarkers of Metastasis, Invasion, and Therapy Stratification in Head and Neck Squamous Cell Carcinoma (2025)
- Cancer Medicine
(A1 Refereed original research article in a scientific journal) - MUC1 and glycan probing of CA19-9 captured biomarkers from cyst fluids and serum provides enhanced recognition of ovarian cancer (2025)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Bioaffinity Recognition of Extracellular Vesicle Glycosylations (2024) Extracellular Vesicles as Matrix Messengers Islam, Khirul; Leivo, Janne
(B2 Non-refereed book chapter or chapter in a compilation book) - Identification of stemness-related glycosylation changes in head and neck squamous cell carcinoma (2024)
- BMC Cancer
(A1 Refereed original research article in a scientific journal) - Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches (2024)
- Journal of Extracellular Vesicles
(Other publication) - Tetraspanin immunoassay for the detection of extracellular vesicles and renal cell carcinoma (2024)
- Nano select
(A1 Refereed original research article in a scientific journal) - Aberrant glycosylation of α3 integrins as diagnostic markers in epithelial ovarian cancer (2023)
- Clinica Chimica Acta
(A1 Refereed original research article in a scientific journal) - Lectins as potential tools for cancer biomarker discovery from extracellular vesicles (2023)
- Biomarker research
(A2 Refereed review article in a scientific journal ) - Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth (2023)
- Oncogene
(A1 Refereed original research article in a scientific journal) - Diagnostic potential of nanoparticle aided assays for MUC16 and MUC1 glycovariants in ovarian cancer (2022)
- International Journal of Cancer
(A1 Refereed original research article in a scientific journal) - Integrins are enriched on aberrantly fucosylated tumour‐derived urinary extracellular vesicles (2022)
- Journal of Extracellular Biology
(A1 Refereed original research article in a scientific journal) - Primary breast cancer biomarkers based on glycosylation and extracellular vesicles detected from human serum (2022)
- Cancer reports
(A1 Refereed original research article in a scientific journal) - Detection of bladder cancer with aberrantly fucosylated ITGA3 (2021)
- Analytical Biochemistry
(A1 Refereed original research article in a scientific journal) - Nanoparticle-aided detection of colorectal cancer-associated glycoconjugates of extracellular vesicles in human serum (2021)
- International Journal of Molecular Sciences
(A1 Refereed original research article in a scientific journal) - Phage Display Selection of an Anti-Idiotype-Antibody with Broad-Specificity to Deoxynivalenol Mycotoxins (2021)
- Toxins
(A1 Refereed original research article in a scientific journal) - Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles (2021)
- Journal of Extracellular Vesicles
(A1 Refereed original research article in a scientific journal) - Glycovariant-based lateral flow immunoassay to detect ovarian cancer–associated serum CA125 (2020)
- Communications Biology
(A1 Refereed original research article in a scientific journal) - A Nanoparticle-Based Approach for the Detection of Extracellular Vesicles (2019)
- Scientific Reports
(A1 Refereed original research article in a scientific journal) - Detection of Food Taints and Contaminants Using Novel Engineered Antibodies (2019) Rapid Antibody-based Technologies in Food Analysis Leivo J., Lamminmäki U.
(A3 Refereed book chapter or chapter in a compilation book)