Seija Grenman
Professor, emerita MD PhD

Adjunct Professor, Faculty of Medicine (Faculty of Medicine)
Department of Obstetrics and Gynecology
seigre@utu.fi
+358 40 733 6312

Kiinamyllynkatu 4-8
Turku
Turku University Hospital Dept. Obstetrics and Gynecology





Areas of expertise
Gynecologic Oncology; HPV-research

Biography



Professor Seija Grenman has a long history in
promoting women’s health issues both nationally and internationally. At the
national level, she has served as the President of the Finnish Cancer
Foundation 2010-2016 and the president of the Finnish Gynecological
Association  2015 - 2017. Professor
Grenman has also been an active member of the Nordic Society of Obstetrics and
Gynecology (NFOG), first serving as the Chairman of the Scientific Committee
and then as the Chairman of NFOG in 2006-2010. Since 2009 she has been a FIGO
Executive Board Member representing Finland as Vice President in 2015-2018. She
is an ex officio member of the FIGO Committees on Gynecologic Oncology and
Women´s Health and Human Rights (WHHR) as well as the Working Group on Violence
against Women. Her main interests in research are Ovarian Cancer and HPV. She
is the principal investigator at Turku University Hospital in two consortiums
studying ovarian cancer : a national OVCURE-consortium funded by the Finnish
Academy and  an EU-funded HERCULES
consortium. Since 1998 she has collaborated with professor Stina Syrjänen on
the Finnish Family HPV Study including 300 families and newborn babies.



Research



Personalized therapy of Ovarian cancer



Ovarian
cancer research was started as a consortium at the University of Turku in 2009,
but has expanded in 2015 to a consortium supported by the Academy of Finland
and in 2016 to an EU-consortium consisting of 
8 research groups in Finland, Sweden, France and Italy. The main
objectives of the study are to comprehensively characterize high-grade serous
ovarian cancer ( HGS-OvCa) by intergrating and modelling clinical and
biological data (e.g. genetics, transcriptomics, protein binding, drug
screening) from primary, metastatic and relapsed tumors from various anatomical
sites of HGS-OvCa patients, and to establish combinatorial treatment modalities
that effectively kill HGS-OvCa tumor cell subpopulations. The projects have
been supported by the Academy of Finland, Finnish Cancer Foundation, EU-grant
and the Government Special Foundation to Turku University Hospital. 



The Finnish Family HPV Study



The Finnish
Family HPV study is a prospective cohort study conducted at the University of
Turku, Turku Finland. A total of 329 mother, 131 fathers and 331 new born
babies have been recruited to this study between 1998-2002 and the participants
have been followed up since then. The purpose of the study has been to evaluate
the transmission of HPV infection and to identify special risk groups for
persistent HPV infection among family members. Currently the work is focusing
on the effects of HPV-specific immunity on the outcome of HPV infections in
women and in early childhood.



Teaching

Seija Grénman has experience on teaching for a number of years as a clinical teacher until 2010 and as a professor there after. She was nominated as the teacher of the year by medical students in 2001.  



Publications
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Behavior of FDG-avid supradiaphragmatic lymph nodes in PET/CT throughout primary therapy in advanced serous epithelial ovarian cancer: a prospective study (2019) Laasik M, Kemppainen J, Auranen A, Hietanen S, Grénman S, Seppänen M, Hynninen J
(
A1 Journal article – refereed)

Decorin Expression in Human Vulva Carcinoma: Oncosuppressive Effect of Decorin cDNA Transduction on Carcinoma Cells (2019)
Journal of Histochemistry and Cytochemistry
Marie C. Nyman, Anne B. Jokilammi, Pia C. Boström, Samu H. Kurki, Annele O. Sainio, Seija E. Grenman, Katri J. Orte, Sakari H. Hietanen, Klaus Elenius, Hannu T. Järveläinen
(
A1 Journal article – refereed)

Prospective Longitudinal ctDNA Workflow Reveals Clinically Actionable Alterations in Ovarian Cancer (2019)
JCO Precision Oncology
Oikkonen J, Zhang KY, Salminen L, Schulman I, Lavikka K, Andersson N, Ojanperä E, Hietanen S, Grenman S, Lehtonen R, Huhtinen K, Carpen O, Hynninen J, Färkkilä A, Hautaniemi S
(
A1 Journal article – refereed)

Revised FIGO staging for carcinoma of the cervix uteri (2019)
International Journal of Gynecology and Obstetrics
Bhatla N, Berek JS, Fredes MC, Denny LA, Grenman S, Karunaratne K, Kehoe ST, Konishi I, Olawaiye AB, Prat J, Sankaranarayanan R
(
B1 Journal article)

A Functional Homologous Recombination Assay Predicts Primary Chemotherapy Response and Long-Term Survival in Ovarian Cancer Patients (2018)
Clinical Cancer Research
Tumiati M, Hietanen S, Hynninen J, Pietilä E, Färkkilä A, Kaipio K, Roering P, Huhtinen K, Alkodsi A, Li Y, Lehtonen R, Erkan EP, Tuominen MM, Lehti K, Hautaniemi SK, Grénman S, Vähärautio A, Carpén O, Kauppi L
(
A1 Journal article – refereed)

Clinical Value of F-18-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Response Evaluation after Primary Treatment of Advanced Epithelial Ovarian Cancer (2018)
Clinical Oncology
J. Hynninen, M. Laasik, T. Vallius, J. Kemppainen, S. Grönroos, J. Virtanen, J. Casado, S. Hautaniemi, S. Grenman, M. Seppänen, A. Auranen
(
A1 Journal article – refereed)

Combined ASRGL1 and p53 immunohistochemistry as an independent predictor of survival in endometrioid endometrial carcinoma (2018)
Gynecologic Oncology
Huvila J, Laajala TD, Edqvist PH, Mardinoglu A, Talve L, Ponten F, Grenman S, Carpen O, Aittokallio T, Auranen A
(
A1 Journal article – refereed)

F-18-FDG-PET/CT based total metabolic tumor volume change during neoadjuvant chemotherapy predicts outcome in advanced epithelial ovarian cancer (2018)
European Journal of Nuclear Medicine and Molecular Imaging
Tuulia Vallius, Johanna Hynninen, Jukka Kemppainen, Victor Alves, Kari Auranen, Jaakko Matomäki, Sinikka Oksa,
Johanna Virtanen, Seija Grénman, Annika Auranen, Marko Seppänen

(
A1 Journal article – refereed)

HLA-G and vertical mother-to-child transmission of human papillomavirus infection (2018)
Human Immunology
Karolina Louvanto, Michel Roger, Marie-Claude Faucher, Kari Syrjänen, Seija Grenman, Stina Syrjänen
(
A1 Journal article – refereed)

Identifying differentially methylated sites in samples with varying tumor purity (2018)
Bioinformatics
Antti Häkkinen, Amjad Alkodsi, Chiara Facciotto, Kaiyang Zhang, Katja Kaipio, Sirpa Leppä, Olli Carpén, Seija Grénman, Johanna Hynninen, Sakari Hietanen Rainer Lehtonen, Sampsa Hautaniemi
(
A1 Journal article – refereed)

Mathematical Modeling Predicts Response to Chemotherapy and Drug Combinations in Ovarian Cancer (2018)
Cancer Research
Emilia Kozłowska, Anniina Färkkilä, Tuulia Vallius, Olli Carpén, Jukka Kemppainen, Seija Grénman, Rainer Lehtonen, Johanna Hynninen, Sakari Hietanen, Sampsa Hautaniemi
(
A1 Journal article – refereed)

Psychosexual health in gynecologic cancer (2018)
International Journal of Gynecology and Obstetrics
Boa R, Grenman S
(
B1 Journal article)

Association of asymptomatic bacterial vaginosis with persistence of female genital human papillomavirus infection. (2017)
European Journal of Clinical Microbiology and Infectious Diseases
Kero K, Rautava, J, Syrjänen K, Grenman S, Syrjänen S.
(
A1 Journal article – refereed)

Breast Milk Is a Potential Vehicle for Human Papillomavirus Transmission to Oral Mucosa of the Spouse (2017)
Pediatric Infectious Disease Journal
Karolina Louvanto, Marja Sarkola, Marjut Rintala, Kari Syrjänen, Seija Grenman, Stina Syrjänen
(
A1 Journal article – refereed)

Chemotherapy vs tamoxifen in platinum-resistant ovarian cancer: a phase III, randomised, multicentre trial (Ovaresist) (2017)
British Journal of Cancer
Lindemann K, Gibbs E, Avall-Lundqvist E, Christensen RD, Woie K, Kalling M, Auranen A, Grenman S, Hoegberg T, Rosenberg P, Skeie-Jensen T, Hjerpe E, Dorum A, Gebski V, Kristensen G
(
A1 Journal article – refereed)

Hormonikierukka ja rintasyöpä - miten tuoretta rekisteritutkimusta pitäisi tulkita? (2017)
Lääkärilehti
Grénman S, Tiitinen A
(
D1 Article in a trade journal)

Long-term Follow-up After Endometrial Ablation in Finland Cancer Risks and Later Hysterectomies (2017)
Obstetrics and Gynecology
Soini T, Rantanen M, Paavonen J, Grenman S, Maenpaa J, Pukkala E, Gissler M, Hurskainen R
(
A1 Journal article – refereed)

Paclitaxel, Carboplatin and 1,25-D3 Inhibit Proliferation of Endometrial Cancer Cells In Vitro (2017)
Anticancer Research
Kuittinen T, Rovio P, Staff S, Luukkaala T, Kallioniemi A, Grenman S, Laurila M, Mäenpää J
(
A1 Journal article – refereed)

Physical state and copy numbers of HPV16 in oral asymptomatic infections that persisted or cleared during the 6-year follow-up (2017)
Journal of General Virology
Lorenzi Adriana, Rautava Jaana, Kero Katja, Syrjänen Kari, Longatto Adhemar, Grenman Seija, Syrjänen Stina
(
A1 Journal article – refereed)

Postoperative human epididymis protein 4 predicts primary therapy outcome in advanced epithelial ovarian cancer (2017)
Tumor Biology
Vallius T, Hynninen J, Auranen A, Matomaki J, Oksa S, Roering P, Grenman S
(
A1 Journal article – refereed)


Last updated on 2019-20-09 at 02:22