A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
The association of HLA-G polymorphism with oral and genital HPV infection in men
Tekijät: Suominen Nelli T., Jaakola Anna J., Roger Michel, Faucher Marie‑Claude, Syrjänen Kari J., Grénman Seija E., Syrjänen Stina M., Louvanto Karolina
Kustantaja: SPRINGER
Julkaisuvuosi: 2022
Journal: European Journal of Clinical Microbiology and Infectious Diseases
Lehden akronyymi: EUR J CLIN MICROBIOL
Vuosikerta: 41
Numero: 2
Aloitussivu: 219
Lopetussivu: 226
Sivujen määrä: 8
ISSN: 0934-9723
eISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-021-04362-8
Verkko-osoite: https://link.springer.com/article/10.1007%2Fs10096-021-04362-8
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/68124967
The host genetic factors that influence the natural history of human papillomavirus (HPV) infection in men are not well known. Our aim was to evaluate the role of human leukocyte antigen (HLA)-G polymorphism in oral and genital HPV infection in men. Altogether, 130 men from the Finnish Family HPV Study, with a 6-year follow-up, were included in the analyses. HLA-G alleles were tested by direct sequencing. Oral, urethral, and semen samples were collected and analyzed for 24 different HPV genotypes. Unconditional logistic regression was used to determine associations between HLA-G alleles and genotypes with HPV infection and its outcomes. Overall, eight different HLA-G alleles were identified with 15 different HLA-G genotype combinations. The most common HLA-G allele among the men was G*01:01:01 (86.2%, n = 112) followed by G*01:01:02 (36.2%, n = 47). Allele G*01:01:02 showed to be protective against any- and high-risk (HR) oral HPV (OR range of 0.20-0.24, 95% CI range of 0.06-0.85). Men having allele G*01:01:01 showed a reduced risk for incident (OR 0.30, 95% CI 0.11-0.84) and persistent (OR 0.24, 95% CI 0.08-0.69) oral infections. Allele G*01:01:03 was associated with increased risk for urethral HR-HPV infections (OR 4.94, 95% CI 1.34-18.27). Among self-reported demographic data, genotype G*01:01:01/01:01:03 was associated with an increased risk for oral warts (OR 8.00, 95% CI 1.23-51.89) and allele G*01:03:01 increased the risk of pollen and/or animal allergy (OR 13.59, 95% CI 1.57-117.25). To conclude, HLA-G polymorphism in men largely impacts the outcome of an oral HPV infection and seems to associate with self-reported allergies.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
