Seija Grenman
Professor, emerita MD PhD
Department of Obstetrics and Gynecology seigre@utu.fi +358 40 733 6312 Kiinamyllynkatu 4-8 Turku |
Gynekologinen syöpä, HPV-tutkimus
Professor Seija Grenman has a long history in
promoting women’s health issues both nationally and internationally. At the
national level, she has served as the President of the Finnish Cancer
Foundation 2010-2016 and the president of the Finnish Gynecological
Association 2015 - 2017. Professor
Grenman has also been an active member of the Nordic Society of Obstetrics and
Gynecology (NFOG), first serving as the Chairman of the Scientific Committee
and then as the Chairman of NFOG in 2006-2010. Since 2009 she has been a FIGO
Executive Board Member representing Finland as Vice President in 2015-2018. She
is an ex officio member of the FIGO Committees on Gynecologic Oncology and
Women´s Health and Human Rights (WHHR) as well as the Working Group on Violence
against Women. Her main interests in research are Ovarian Cancer and HPV. She
is the principal investigator at Turku University Hospital in two consortiums
studying ovarian cancer : a national OVCURE-consortium funded by the Finnish
Academy and an EU-funded HERCULES
consortium. Since 1998 she has collaborated with professor Stina Syrjänen on
the Finnish Family HPV Study including 300 families and newborn babies.
Personalized therapy of Ovarian cancer
Ovarian
cancer research was started as a consortium at the University of Turku in 2009,
but has expanded in 2015 to a consortium supported by the Academy of Finland
and in 2016 to an EU-consortium consisting of
8 research groups in Finland, Sweden, France and Italy. The main
objectives of the study are to comprehensively characterize high-grade serous
ovarian cancer ( HGS-OvCa) by intergrating and modelling clinical and
biological data (e.g. genetics, transcriptomics, protein binding, drug
screening) from primary, metastatic and relapsed tumors from various anatomical
sites of HGS-OvCa patients, and to establish combinatorial treatment modalities
that effectively kill HGS-OvCa tumor cell subpopulations. The projects have
been supported by the Academy of Finland, Finnish Cancer Foundation, EU-grant
and the Government Special Foundation to Turku University Hospital.
The Finnish Family HPV Study
The Finnish
Family HPV study is a prospective cohort study conducted at the University of
Turku, Turku Finland. A total of 329 mother, 131 fathers and 331 new born
babies have been recruited to this study between 1998-2002 and the participants
have been followed up since then. The purpose of the study has been to evaluate
the transmission of HPV infection and to identify special risk groups for
persistent HPV infection among family members. Currently the work is focusing
on the effects of HPV-specific immunity on the outcome of HPV infections in
women and in early childhood.
Seija Grénman has experience on teaching for a number of years as a clinical teacher until 2010 and as a professor there after. She was nominated as the teacher of the year by medical students in 2001.
- Helicobacter pylori multiplex serology and its dynamics within families during a 3-year prospective follow-upPeripheral Blood T-lymphocyte Phenotypes in Mother-Child Pairs Stratified by the Maternal HPV Status: Persistent HPV16 vs. HPV-Negative: A Case-Control Study (2025)
- International Journal of Infectious Diseases
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Gestational diabetes and pregnancy outcome in Kurdish, Somali and general population in Finland (2024)
- European Journal of Public Health
(Abstrakti) - Impact of Different Cofactors on Naturally Acquired Human Papillomavirus Antibody Levels Among Unvaccinated Pregnant Women (2024)
- Viral ImmunologyEuropean Journal of Clinical Microbiology and Infectious Diseases
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Serum IgG antibodies to HPV6 L1, E2, E4, E6, and E7 proteins among children prospectively followed-up for three years (2024)
- Journal of Infectious DiseasesScientific Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Effect of a Second Pregnancy on the HPV Serology in Mothers Followed Up in the Finnish Family HPV StudyCo-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance (2023)
- VirusesNature Communications
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - HLA-G Alleles Impact the Perinatal Father-Child HPV Transmission (2023)
- Current Issues in Molecular Biology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Human papillomavirus concordance between parents and their newborn offspring: Results from the Finnish Family HPV study (2023)
- Journal of Infectious Diseases
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Human polyomavirus BKPyV and JCPyV serostatus has no impact on women´s human papillomavirus infection outcome (2023)
- Frontiers in Cellular and Infection Microbiology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - IgG Seroreactivites to Viral Capsid Protein VP1 of JC and BK Polyomaviruses in Children at Early Ages with Special Reference to Parental CofactorsALDH1A1-related stemness in high-grade serous ovarian cancer is a negative prognostic indicator but potentially targetable by EGFR/mTOR-PI3K/aurora kinase inhibitors (2023)
- ChildrenJournal of Pathology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Seroprevalence of polyomaviruses BK and JC in Finnish women and their spouses followed-up for three years (2023)
- Scientific Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Effects of Wee1 inhibitor adavosertib on patient-derived high-grade serous ovarian cancer cells are multiple and independent of homologous recombination status (2022)
- Frontiers in Oncology
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Maternal HPV-antibodies and seroconversion to HPV in children during the first 3 years of life (2022)
- Scientific Reports
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Outcomes of HPV type-specific serostatus do not associate with oral or genital HPV-carriage in non-vaccinated women followed for three years (2022)
- BMC Women's Health
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - (2022)
- Viruses
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - The association of HLA-G polymorphism with oral and genital HPV infection in men (2022)
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Aggressive and recurrent ovarian cancers upregulate ephrinA5, a non-canonical effector of EphA2 signaling duality (2021)
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - (2021)
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - HLA-G polymorphism impacts the outcome of oral HPV infections in women (2021)
- BMC Infectious Diseases
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - Oral Human Papillomavirus Infection in Children during the First 6 Years of Life, Finland (2021)
- Emerging Infectious Diseases
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä ) - (2020)
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )