A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Helicobacter pylori multiplex serology and its dynamics within families during a 3-year prospective follow-up




TekijätSyrjanen, Kari; Rinne, Sanni; Koskela, Nea; Michels, Birgitta; Butt, Julia; Grenman, Seija; Waterboer, Tim; Syrjänen, Stina; Louvanto, Karolina

KustantajaElsevier BV

KustannuspaikkaLondon

Julkaisuvuosi2025

JournalInternational Journal of Infectious Diseases

Tietokannassa oleva lehden nimiInternational Journal of Infectious Diseases

Lehden akronyymiINT J INFECT DIS

Artikkelin numero107893

Vuosikerta155

Sivujen määrä8

ISSN1201-9712

eISSN1878-3511

DOIhttps://doi.org/10.1016/j.ijid.2025.107893

Verkko-osoitehttps://doi.org/10.1016/j.ijid.2025.107893

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/491913116


Tiivistelmä

Objectives: Transmission routes of Helicobacter pylori (Hp) have been extensively studied, but many aspects remain unclear. This study explored the dynamics of multiplex Hp serology within regular families during a 36-month prospective follow-up.

Methods: Altogether, 329 families from the Finnish Family HPV study were subjected to sequential blood sampling and now tested also for six Hp proteins, HP0010, HP0073, HP0547, HP0875, HP0887, and HP1564, using multiplex serology assay.

Results: Hp seropositivity, defined as being seropositive to at least three of the six Hp proteins, was more common among the fathers (20%) than mothers (10%). After maternal antibody decay, only a few children tested Hp-seropositive at later follow-up visits, indicating that acquisition of Hp infection is practically non-existent (0.4-2.0%) at an early age. No evidence was found to support the person-to-person transmission of Hp in this cohort because there was no correlation in Hp seropositivity or antibody levels between the spouses and/or their offspring, and individuals who were Hp-seropositive did not seem to increase the risk of other family members to co-test Hp-seropositive.

Conclusions: Our results perfectly agree with a recently published register-linkage study from Finland, where Hp and Hp-related co-morbidity are predicted to disappear among the native Finns during the 21st century.


Ladattava julkaisu

This is an electronic reprint of the original article.
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Julkaisussa olevat rahoitustiedot
This study was financially supported by the Academy of Finland [SS, KL], Päivikki and Sakari Sohlberg Foundation [SS, SG, KL], Sigrid Jusélius Foundation [KL], and the Finnish Medical Foundation [KL].


Last updated on 2025-02-06 at 10:37