A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Oral Human Papillomavirus Infection in Children during the First 6 Years of Life, Finland
Tekijät: Syrjänen Stina, Rintala Marjut, Sarkola Marja, Willberg Jaana, Rautava Jaana, Koskimaa Hanna, Paaso Anna, Syrjänen Kari, Grénman Seija, Louvanto Karolina
Kustantaja: CENTERS DISEASE CONTROL & PREVENTION
Julkaisuvuosi: 2021
Journal: Emerging Infectious Diseases
Tietokannassa oleva lehden nimi: EMERGING INFECTIOUS DISEASES
Lehden akronyymi: EMERG INFECT DIS
Vuosikerta: 27
Numero: 3
Aloitussivu: 759
Lopetussivu: 766
Sivujen määrä: 8
ISSN: 1080-6040
eISSN: 1080-6059
DOI: https://doi.org/10.3201/eid2703.202721
Verkko-osoite: https://wwwnc.cdc.gov/eid/article/27/3/20-2721_article
Rinnakkaistallenteen osoite: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920652/
Human papillomavirus (HPV) infections are found in children, but transmission modes and outcomes are incompletely understood. We evaluated oral samples from 331 children in Finland who participated in the Finnish Family HPV Study from birth during 9 follow-up visits (mean time 51.9 months). We tested samples for 24 HPV genotypes. Oral HPV prevalence for children varied from 8.7% (at a 36-month visit) to 22.8% (at birth), and 18 HPV genotypes were identified. HPV16 was the most prevalent type to persist, followed by HPV18, HPV33, and HPV6. Persistent, oral, high-risk HPV infection for children was associated with oral HPV carriage of the mother at birth and seroconversion of the mother to high-risk HPV during follow-up (odds ratio 1.60-1.92, 95% CI 1.02-2.74). Children acquire their first oral HPV infection at an early age. The HPV status of the mother has a major impact on the outcome of oral HPV persistence for her offspring.
