Targeting Gut Microbiota to Treat Hypertension: A Systematic Review



: Palmu Joonatan, Lahti Leo, Niiranen Teemu

Publisher: MDPI

: 2021

: International Journal of Environmental Research and Public Health

: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH

: INT J ENV RES PUB HE

: ARTN 1248

: 18

: 3

: 14

: 1660-4601

DOI: https://doi.org/10.3390/ijerph18031248

: https://research.utu.fi/converis/portal/detail/Publication/53413554


While hypertension remains the leading modifiable risk factor for cardiovascular morbidity and mortality, the pathogenesis of essential hypertension remains only partially understood. Recently, microbial dysbiosis has been associated with multiple chronic diseases closely related to hypertension. In addition, multiple small-scale animal and human studies have provided promising results for the association between gut microbial dysbiosis and hypertension. Animal models and a small human pilot study, have demonstrated that high salt intake, a risk factor for both hypertension and cardiovascular disease, depletes certain Lactobacillus species while oral treatment of Lactobacilli prevented salt-sensitive hypertension. To date, four large cohort studies have reported modest associations between gut microbiota features and hypertension. In this systematic literature review, we examine the previously reported links between the gut microbiota and hypertension and what is known about the functional mechanisms behind this association.

Last updated on 2024-26-11 at 21:06