A2 Refereed review article in a scientific journal
Targeting Gut Microbiota to Treat Hypertension: A Systematic Review
Authors: Palmu Joonatan, Lahti Leo, Niiranen Teemu
Publisher: MDPI
Publication year: 2021
Journal: International Journal of Environmental Research and Public Health
Journal name in source: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Journal acronym: INT J ENV RES PUB HE
Article number: ARTN 1248
Volume: 18
Issue: 3
Number of pages: 14
eISSN: 1660-4601
DOI: https://doi.org/10.3390/ijerph18031248
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/53413554
While hypertension remains the leading modifiable risk factor for cardiovascular morbidity and mortality, the pathogenesis of essential hypertension remains only partially understood. Recently, microbial dysbiosis has been associated with multiple chronic diseases closely related to hypertension. In addition, multiple small-scale animal and human studies have provided promising results for the association between gut microbial dysbiosis and hypertension. Animal models and a small human pilot study, have demonstrated that high salt intake, a risk factor for both hypertension and cardiovascular disease, depletes certain Lactobacillus species while oral treatment of Lactobacilli prevented salt-sensitive hypertension. To date, four large cohort studies have reported modest associations between gut microbiota features and hypertension. In this systematic literature review, we examine the previously reported links between the gut microbiota and hypertension and what is known about the functional mechanisms behind this association.
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