B1 Journal article

p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control

List of Authors: Eskelinen Eeva-Liisa, Kageyama Shun, Komatsu Masaaki


Publication year: 2021

Journal: Molecular & Cellular Oncology

Journal name in source: MOLECULAR & CELLULAR ONCOLOGY

Journal acronym: MOL CELL ONCOL

Volume number: 8

Issue number: 2

Number of pages: 3

DOI: http://dx.doi.org/10.1080/23723556.2021.1890990

Selective autophagy contributes to the degradation of condensates, such as sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous p62 forms gel-like structures, which serve as platforms for autophagosome formation and nuclear factor erythroid 2-related factor 2 (NRF2) activation. Further, p62-mediated NRF2 activation is not cytotoxic, but combination of NRF2 activation with impaired bulk and selective autophagy causes liver injury.

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Last updated on 2021-24-06 at 09:10