Absence of DNA viruses in ameloblastomas
: Jauhiainen, Maria K.; Kelppe, Jetta; Söderlund‐Venermo, Maria; Mäkitie, Antti A.; Sinkkonen, Saku T.; Hagström, Jaana
Publisher: Wiley
: 2026
European Journal of Oral Sciences
: e70092
: 0909-8836
: 1600-0722
DOI: https://doi.org/10.1111/eos.70092
: https://doi.org/10.1111/eos.70092
: https://research.utu.fi/converis/portal/detail/Publication/523064370
Ameloblastomas (ABs) are rare odontogenic benign tumors. Although studies of the molecular pathogenesis have revealed the presence of mutations and altered gene expression, the etiology is unresolved. Viruses cause 10%-15 % of cancers, but their potential role within benign tumors is less studied. This study focuses on the potential presence of herpes-, parvo-, and polyomaviruses in ABs. Thirty DNA viruses comprising herpes-, parvo-, and polyomaviruses were analyzed by qPCR and Luminex-based methods in 11 formalin-fixed paraffin-embedded AB samples. In repeated analyses, the ABs harbored none of the studied large set of viruses. Based on our findings a relevant role of the studied viruses seems unlikely in the pathogenesis of ABs.
:
The authors have nothing to report. The Finska Läkaresällskapet (Antti A. Mäkitie, Maria K. Jauhiainen), The Finnish Medical Association (Maria K. Jauhiainen), Helsingin Lääkäriyhdistys (Maria K. Jauhiainen), State research funding for the University Hospital Research Funds (Grant TYH2024327) (Saku T. Sinkkonen). The Sigrid Jusélius Foundation (Antti A. Mäkitie, Maria Söderlund-Venermo), and the Kirsti and Tor Johansson ‘s Heart and Cancer Foundation (Maria Söderlund-Venermo).
Open access publishing facilitated by Helsingin yliopisto, as part of the Wiley – FinELib agreement.
