Absence of DNA viruses in ameloblastomas - UTU Research Portal

A1 Refereed original research article in a scientific journal

Absence of DNA viruses in ameloblastomas

Authors: Jauhiainen, Maria K.; Kelppe, Jetta; Söderlund‐Venermo, Maria; Mäkitie, Antti A.; Sinkkonen, Saku T.; Hagström, Jaana

Publisher: Wiley

Publication year: 2026

Journal: European Journal of Oral Sciences

Article number: e70092

ISSN: 0909-8836

eISSN: 1600-0722

DOI: https://doi.org/10.1111/eos.70092

Publication's open availability at the time of reporting: Open Access

Publication channel's open availability : Partially Open Access publication channel

Web address : https://doi.org/10.1111/eos.70092

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/523064370

Self-archived copy's licence: CC BY

Self-archived copy's version: Publisher`s PDF

Abstract

Ameloblastomas (ABs) are rare odontogenic benign tumors. Although studies of the molecular pathogenesis have revealed the presence of mutations and altered gene expression, the etiology is unresolved. Viruses cause 10%-15 % of cancers, but their potential role within benign tumors is less studied. This study focuses on the potential presence of herpes-, parvo-, and polyomaviruses in ABs. Thirty DNA viruses comprising herpes-, parvo-, and polyomaviruses were analyzed by qPCR and Luminex-based methods in 11 formalin-fixed paraffin-embedded AB samples. In repeated analyses, the ABs harbored none of the studied large set of viruses. Based on our findings a relevant role of the studied viruses seems unlikely in the pathogenesis of ABs.

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European J Oral Sciences - 2026 - Jauhiainen - Absence of DNA viruses in ameloblastomas.pdf

Funding information in the publication:
The authors have nothing to report. The Finska Läkaresällskapet (Antti A. Mäkitie, Maria K. Jauhiainen), The Finnish Medical Association (Maria K. Jauhiainen), Helsingin Lääkäriyhdistys (Maria K. Jauhiainen), State research funding for the University Hospital Research Funds (Grant TYH2024327) (Saku T. Sinkkonen). The Sigrid Jusélius Foundation (Antti A. Mäkitie, Maria Söderlund-Venermo), and the Kirsti and Tor Johansson ‘s Heart and Cancer Foundation (Maria Söderlund-Venermo).

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