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Absence of DNA viruses in ameloblastomas



Tekijät: Jauhiainen, Maria K.; Kelppe, Jetta; Söderlund‐Venermo, Maria; Mäkitie, Antti A.; Sinkkonen, Saku T.; Hagström, Jaana

Kustantaja: Wiley

Julkaisuvuosi: 2026

Lehti: European Journal of Oral Sciences

Artikkelin numero: e70092

ISSN: 0909-8836

eISSN: 1600-0722

DOI: https://doi.org/10.1111/eos.70092

Julkaisun avoimuus kirjaamishetkellä: Avoimesti saatavilla

Julkaisukanavan avoimuus : Osittain avoin julkaisukanava

Verkko-osoite: https://doi.org/10.1111/eos.70092

Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/523064370

Rinnakkaistallenteen lisenssi: CC BY

Rinnakkaistallennetun julkaisun versio: Kustantajan versio


Tiivistelmä

Ameloblastomas (ABs) are rare odontogenic benign tumors. Although studies of the molecular pathogenesis have revealed the presence of mutations and altered gene expression, the etiology is unresolved. Viruses cause 10%-15 % of cancers, but their potential role within benign tumors is less studied. This study focuses on the potential presence of herpes-, parvo-, and polyomaviruses in ABs. Thirty DNA viruses comprising herpes-, parvo-, and polyomaviruses were analyzed by qPCR and Luminex-based methods in 11 formalin-fixed paraffin-embedded AB samples. In repeated analyses, the ABs harbored none of the studied large set of viruses. Based on our findings a relevant role of the studied viruses seems unlikely in the pathogenesis of ABs.


Ladattava julkaisu

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.

Julkaisussa olevat rahoitustiedot: 
The authors have nothing to report. The Finska Läkaresällskapet (Antti A. Mäkitie, Maria K. Jauhiainen), The Finnish Medical Association (Maria K. Jauhiainen), Helsingin Lääkäriyhdistys (Maria K. Jauhiainen), State research funding for the University Hospital Research Funds (Grant TYH2024327) (Saku T. Sinkkonen). The Sigrid Jusélius Foundation (Antti A. Mäkitie, Maria Söderlund-Venermo), and the Kirsti and Tor Johansson ‘s Heart and Cancer Foundation (Maria Söderlund-Venermo).

Open access publishing facilitated by Helsingin yliopisto, as part of the Wiley – FinELib agreement.


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