The feasibility of [F-18]EF5-PET/CT to image hypoxia in ovarian tumors: a clinical study

: Maren Laasik, Johanna Hynninen, Sarita Forsback, Tommi Noponen, Marko Seppänen, Sakari Hietanen

Publisher: SPRINGER

: 2020

: EJNMMI Research

: EJNMMI RESEARCH

: EJNMMI RES

: ARTN 103

: 10

: 1

: 7

: 2191-219X

DOI: https://doi.org/10.1186/s13550-020-00689-z

: https://research.utu.fi/converis/portal/detail/Publication/50595242

Rationale Evaluation of the feasibility of [F-18]EF5-PET/CT scan in identifying hypoxic lesions in ovarian tumors in prospective clinical setting. Methods Fifteen patients with a suspected malignant ovarian tumor were scanned with [F-18]EF5 and [F-18]FDG-PET/CT preoperatively. The distribution of [F-18]EF5-uptake, total intraabdominal metabolic tumor volume (TMTV), and hypoxic subvolume (HSV) were assessed. Results [F-18]EF5-PET/CT suggested hypoxia in 47% (7/15) patients. The median HSV was 87 cm(3)(31% of TMTV). The [F-18]EF5-uptake was detected in primary tumors and in four patients also in intra-abdominal metastases. The [F-18]EF5-uptake in cancer tissue was low compared to physiological excretory pathways, complicating the interpretation of PET/CT images. Conclusions [F-18]EF5-PET/CT is not feasible in ovarian cancer imaging in clinical setting due to physiological intra-abdominal [F-18]EF5-accumulation. However, it may be useful when used complementarily to FDG-PET/CT.

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