A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
The feasibility of [F-18]EF5-PET/CT to image hypoxia in ovarian tumors: a clinical study
Tekijät: Maren Laasik, Johanna Hynninen, Sarita Forsback, Tommi Noponen, Marko Seppänen, Sakari Hietanen
Kustantaja: SPRINGER
Julkaisuvuosi: 2020
Journal: EJNMMI Research
Tietokannassa oleva lehden nimi: EJNMMI RESEARCH
Lehden akronyymi: EJNMMI RES
Artikkelin numero: ARTN 103
Vuosikerta: 10
Numero: 1
Sivujen määrä: 7
ISSN: 2191-219X
eISSN: 2191-219X
DOI: https://doi.org/10.1186/s13550-020-00689-z
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/50595242
Rationale Evaluation of the feasibility of [F-18]EF5-PET/CT scan in identifying hypoxic lesions in ovarian tumors in prospective clinical setting. Methods Fifteen patients with a suspected malignant ovarian tumor were scanned with [F-18]EF5 and [F-18]FDG-PET/CT preoperatively. The distribution of [F-18]EF5-uptake, total intraabdominal metabolic tumor volume (TMTV), and hypoxic subvolume (HSV) were assessed. Results [F-18]EF5-PET/CT suggested hypoxia in 47% (7/15) patients. The median HSV was 87 cm(3)(31% of TMTV). The [F-18]EF5-uptake was detected in primary tumors and in four patients also in intra-abdominal metastases. The [F-18]EF5-uptake in cancer tissue was low compared to physiological excretory pathways, complicating the interpretation of PET/CT images. Conclusions [F-18]EF5-PET/CT is not feasible in ovarian cancer imaging in clinical setting due to physiological intra-abdominal [F-18]EF5-accumulation. However, it may be useful when used complementarily to FDG-PET/CT.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
