Self-Synthesizing Nanorods from Dynamic Combinatorial Libraries against Drug Resistant Cancer



: Cao Yu, Yang Jian, Eichin Dominik, Zhao Fangzhe, Qi Dawei, Kahari Laura, Jia Chunman, Peurla Markus, Rosenholm Jessica M, Zhao Zhao, Jalkanen Sirpa, Li Jianwei

Publisher: Wiley

: 2021

: Angewandte Chemie International Edition

: Angewandte Chemie (International ed. in English)

: Angew Chem Int Ed Engl

: 60

: 6

: 3062

: 3070

: 10

: 1433-7851

: 1521-3773

DOI: https://doi.org/10.1002/anie.202010937

: https://research.utu.fi/converis/portal/detail/Publication/49809853


Molecular self-assembly has been widely used to develop nanocarriers for drug delivery; however, most have unsatisfactory drug loading capacity (DLC) and the dilemma between stimuli-responsiveness and stability, stagnating their translational process. Here we overcame these drawbacks using dynamic combinatorial chemistry. A carrier molecule was spontaneously and quantitatively synthesized, aided by co-self-assembly with a template molecule and an anti-cancer drug doxorubicin (DOX) from a dynamic combinatorial library that was operated by disulfide exchange under thermodynamic control. The highly selective synthesis guaranteed a stable yet pH- and redox- responsive nanocarrier with a maximized DLC of 40.1% and an enhanced drug potency to fight DOX resistance in vitro and in vivo . Our findings suggested that harnessing the interplay between synthesis and self-assembly in complex chemical systems could yield functional nanomaterials for advanced applications.

Last updated on 2024-26-11 at 12:56