A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Self-Synthesizing Nanorods from Dynamic Combinatorial Libraries against Drug Resistant Cancer




TekijätCao Yu, Yang Jian, Eichin Dominik, Zhao Fangzhe, Qi Dawei, Kahari Laura, Jia Chunman, Peurla Markus, Rosenholm Jessica M, Zhao Zhao, Jalkanen Sirpa, Li Jianwei

KustantajaWiley

Julkaisuvuosi2021

JournalAngewandte Chemie International Edition

Tietokannassa oleva lehden nimiAngewandte Chemie (International ed. in English)

Lehden akronyymiAngew Chem Int Ed Engl

Vuosikerta60

Numero6

Aloitussivu3062

Lopetussivu3070

Sivujen määrä10

ISSN1433-7851

eISSN1521-3773

DOIhttps://doi.org/10.1002/anie.202010937

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/49809853


Tiivistelmä
Molecular self-assembly has been widely used to develop nanocarriers for drug delivery; however, most have unsatisfactory drug loading capacity (DLC) and the dilemma between stimuli-responsiveness and stability, stagnating their translational process. Here we overcame these drawbacks using dynamic combinatorial chemistry. A carrier molecule was spontaneously and quantitatively synthesized, aided by co-self-assembly with a template molecule and an anti-cancer drug doxorubicin (DOX) from a dynamic combinatorial library that was operated by disulfide exchange under thermodynamic control. The highly selective synthesis guaranteed a stable yet pH- and redox- responsive nanocarrier with a maximized DLC of 40.1% and an enhanced drug potency to fight DOX resistance in vitro and in vivo . Our findings suggested that harnessing the interplay between synthesis and self-assembly in complex chemical systems could yield functional nanomaterials for advanced applications.

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Last updated on 2024-26-11 at 12:56