A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Self-Synthesizing Nanorods from Dynamic Combinatorial Libraries against Drug Resistant Cancer

Julkaisun tekijät: Cao Y, Yang J, Eichin D, Zhao F, Qi D, Kahari L, Jia C, Peurla M, Rosenholm JM, Zhao Z, Jalkanen S, Li J

Julkaisuvuosi: 2021

Journal: Angewandte Chemie International Edition

Tietokannassa oleva lehden nimi: Angewandte Chemie (International ed. in English)

Lehden akronyymi: Angew Chem Int Ed Engl

Volyymi: 60

Julkaisunumero: 6

Sivujen määrä: 10

ISSN: 1433-7851

eISSN: 1521-3773

DOI: http://dx.doi.org/10.1002/anie.202010937

Molecular self-assembly has been widely used to develop nanocarriers for drug delivery; however, most have unsatisfactory drug loading capacity (DLC) and the dilemma between stimuli-responsiveness and stability, stagnating their translational process. Here we overcame these drawbacks using dynamic combinatorial chemistry. A carrier molecule was spontaneously and quantitatively synthesized, aided by co-self-assembly with a template molecule and an anti-cancer drug doxorubicin (DOX) from a dynamic combinatorial library that was operated by disulfide exchange under thermodynamic control. The highly selective synthesis guaranteed a stable yet pH- and redox- responsive nanocarrier with a maximized DLC of 40.1% and an enhanced drug potency to fight DOX resistance in vitro and in vivo . Our findings suggested that harnessing the interplay between synthesis and self-assembly in complex chemical systems could yield functional nanomaterials for advanced applications.

Last updated on 2021-24-06 at 11:02