A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Self-Synthesizing Nanorods from Dynamic Combinatorial Libraries against Drug Resistant Cancer
Julkaisun tekijät: Cao Y, Yang J, Eichin D, Zhao F, Qi D, Kahari L, Jia C, Peurla M, Rosenholm JM, Zhao Z, Jalkanen S, Li J
Julkaisuvuosi: 2021
Journal: Angewandte Chemie International Edition
Tietokannassa oleva lehden nimi: Angewandte Chemie (International ed. in English)
Lehden akronyymi: Angew Chem Int Ed Engl
Volyymi: 60
Julkaisunumero: 6
Sivujen määrä: 10
ISSN: 1433-7851
eISSN: 1521-3773
DOI: http://dx.doi.org/10.1002/anie.202010937
Tiivistelmä
Molecular self-assembly has been widely used to develop nanocarriers for drug delivery; however, most have unsatisfactory drug loading capacity (DLC) and the dilemma between stimuli-responsiveness and stability, stagnating their translational process. Here we overcame these drawbacks using dynamic combinatorial chemistry. A carrier molecule was spontaneously and quantitatively synthesized, aided by co-self-assembly with a template molecule and an anti-cancer drug doxorubicin (DOX) from a dynamic combinatorial library that was operated by disulfide exchange under thermodynamic control. The highly selective synthesis guaranteed a stable yet pH- and redox- responsive nanocarrier with a maximized DLC of 40.1% and an enhanced drug potency to fight DOX resistance in vitro and in vivo . Our findings suggested that harnessing the interplay between synthesis and self-assembly in complex chemical systems could yield functional nanomaterials for advanced applications.
Molecular self-assembly has been widely used to develop nanocarriers for drug delivery; however, most have unsatisfactory drug loading capacity (DLC) and the dilemma between stimuli-responsiveness and stability, stagnating their translational process. Here we overcame these drawbacks using dynamic combinatorial chemistry. A carrier molecule was spontaneously and quantitatively synthesized, aided by co-self-assembly with a template molecule and an anti-cancer drug doxorubicin (DOX) from a dynamic combinatorial library that was operated by disulfide exchange under thermodynamic control. The highly selective synthesis guaranteed a stable yet pH- and redox- responsive nanocarrier with a maximized DLC of 40.1% and an enhanced drug potency to fight DOX resistance in vitro and in vivo . Our findings suggested that harnessing the interplay between synthesis and self-assembly in complex chemical systems could yield functional nanomaterials for advanced applications.
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