A1 Refereed original research article in a scientific journal
Self-Synthesizing Nanorods from Dynamic Combinatorial Libraries against Drug Resistant Cancer
Authors: Cao Yu, Yang Jian, Eichin Dominik, Zhao Fangzhe, Qi Dawei, Kahari Laura, Jia Chunman, Peurla Markus, Rosenholm Jessica M, Zhao Zhao, Jalkanen Sirpa, Li Jianwei
Publisher: Wiley
Publication year: 2021
Journal: Angewandte Chemie International Edition
Journal name in source: Angewandte Chemie (International ed. in English)
Journal acronym: Angew Chem Int Ed Engl
Volume: 60
Issue: 6
First page : 3062
Last page: 3070
Number of pages: 10
ISSN: 1433-7851
eISSN: 1521-3773
DOI: https://doi.org/10.1002/anie.202010937
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/49809853
Molecular self-assembly has been widely used to develop nanocarriers for drug delivery; however, most have unsatisfactory drug loading capacity (DLC) and the dilemma between stimuli-responsiveness and stability, stagnating their translational process. Here we overcame these drawbacks using dynamic combinatorial chemistry. A carrier molecule was spontaneously and quantitatively synthesized, aided by co-self-assembly with a template molecule and an anti-cancer drug doxorubicin (DOX) from a dynamic combinatorial library that was operated by disulfide exchange under thermodynamic control. The highly selective synthesis guaranteed a stable yet pH- and redox- responsive nanocarrier with a maximized DLC of 40.1% and an enhanced drug potency to fight DOX resistance in vitro and in vivo . Our findings suggested that harnessing the interplay between synthesis and self-assembly in complex chemical systems could yield functional nanomaterials for advanced applications.
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