Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing



: Zehua Liu, Yunzhan Li, Wei Li, Wenhua Lian, Marianna Kemell, Sami Hietala, Patrícia Figueiredo, Li Li, Ermei Mäkilä, Ming Ma, Jarno Salonen, Jouni T. Hirvonen, Dongfei Liu, Hongbo Zhang, Xianming Deng, Hélder A. Santos

Publisher: ROYAL SOC CHEMISTRY

: 2019

: Materials Horizons

: MATERIALS HORIZONS

: MATER HORIZ

: 6

: 2

: 385

: 393

: 9

: 2051-6347

DOI: https://doi.org/10.1039/c8mh01145a

: https://pubs.rsc.org/en/Content/ArticleLanding/2019/MH/C8MH01145A#!divAbstract

: https://research.utu.fi/converis/portal/detail/Publication/39807705


Here, an oxidation/acid dual-responsive nanohybrids/ark system was produced. The microfluidics-produced nanohybrids endow the system with an orchestrated cascade from wound detection, reactive oxygen species scavenging, drug release to hydrogel formation. The drug release behavior imitates the dynamic wound healing process, thus rendering an enhanced bio-mimetic regeneration.

Last updated on 2024-26-11 at 13:40