A1 Refereed original research article in a scientific journal

Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing



Authors: Zehua Liu, Yunzhan Li, Wei Li, Wenhua Lian, Marianna Kemell, Sami Hietala, Patrícia Figueiredo, Li Li, Ermei Mäkilä, Ming Ma, Jarno Salonen, Jouni T. Hirvonen, Dongfei Liu, Hongbo Zhang, Xianming Deng, Hélder A. Santos

Publisher: ROYAL SOC CHEMISTRY

Publication year: 2019

Journal: Materials Horizons

Journal name in source: MATERIALS HORIZONS

Journal acronym: MATER HORIZ

Volume: 6

Issue: 2

First page : 385

Last page: 393

Number of pages: 9

ISSN: 2051-6347

DOI: https://doi.org/10.1039/c8mh01145a

Web address : https://pubs.rsc.org/en/Content/ArticleLanding/2019/MH/C8MH01145A#!divAbstract

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/39807705


Abstract
Here, an oxidation/acid dual-responsive nanohybrids/ark system was produced. The microfluidics-produced nanohybrids endow the system with an orchestrated cascade from wound detection, reactive oxygen species scavenging, drug release to hydrogel formation. The drug release behavior imitates the dynamic wound healing process, thus rendering an enhanced bio-mimetic regeneration.

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Last updated on 2024-26-11 at 13:40