A1 Refereed original research article in a scientific journal
Base-Filling in Double-Helical Nucleic Acids
Authors: Afari Mark Nana Kwame, Lönnberg Tuomas
Publisher: Wiley-WCH
Publication year: 2024
Journal: ChemistryOpen
Journal name in source: ChemistryOpen
Journal acronym: ChemistryOpen
Article number: e202400088
Volume: 13
Issue: 9
ISSN: 2191-1363
eISSN: 2191-1363
DOI: https://doi.org/10.1002/open.202400088
Web address : https://doi.org/10.1002/open.202400088
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/393492522
Abstract
Base-filling, i. e., post-synthetic furnishing of an oligonucleotide scaffold with base moieties or their analogues, is an interesting alternative to the conventional approach of sequential coupling of building blocks (modified or otherwise). Reversible attachment of the base moieties is particularly attractive as it allows the use of dynamic combinatorial chemistry and usually leads to higher fidelity. This concept article summarizes the various backbones and coupling reactions used for base-filling over the past fifteen years, discusses the impact of base stacking and pairing on efficiency and fidelity and highlights potential and realized applications.
Base-filling, i. e., post-synthetic furnishing of an oligonucleotide scaffold with base moieties or their analogues, is an interesting alternative to the conventional approach of sequential coupling of building blocks (modified or otherwise). Reversible attachment of the base moieties is particularly attractive as it allows the use of dynamic combinatorial chemistry and usually leads to higher fidelity. This concept article summarizes the various backbones and coupling reactions used for base-filling over the past fifteen years, discusses the impact of base stacking and pairing on efficiency and fidelity and highlights potential and realized applications.
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