A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Base-Filling in Double-Helical Nucleic Acids
Tekijät: Afari Mark Nana Kwame, Lönnberg Tuomas
Kustantaja: Wiley-WCH
Julkaisuvuosi: 2024
Journal: ChemistryOpen
Tietokannassa oleva lehden nimi: ChemistryOpen
Lehden akronyymi: ChemistryOpen
Artikkelin numero: e202400088
Vuosikerta: 13
Numero: 9
ISSN: 2191-1363
eISSN: 2191-1363
DOI: https://doi.org/10.1002/open.202400088
Verkko-osoite: https://doi.org/10.1002/open.202400088
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/393492522
Tiivistelmä
Base-filling, i. e., post-synthetic furnishing of an oligonucleotide scaffold with base moieties or their analogues, is an interesting alternative to the conventional approach of sequential coupling of building blocks (modified or otherwise). Reversible attachment of the base moieties is particularly attractive as it allows the use of dynamic combinatorial chemistry and usually leads to higher fidelity. This concept article summarizes the various backbones and coupling reactions used for base-filling over the past fifteen years, discusses the impact of base stacking and pairing on efficiency and fidelity and highlights potential and realized applications.
Base-filling, i. e., post-synthetic furnishing of an oligonucleotide scaffold with base moieties or their analogues, is an interesting alternative to the conventional approach of sequential coupling of building blocks (modified or otherwise). Reversible attachment of the base moieties is particularly attractive as it allows the use of dynamic combinatorial chemistry and usually leads to higher fidelity. This concept article summarizes the various backbones and coupling reactions used for base-filling over the past fifteen years, discusses the impact of base stacking and pairing on efficiency and fidelity and highlights potential and realized applications.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
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