A1 Refereed original research article in a scientific journal

Base-Filling in Double-Helical Nucleic Acids




AuthorsAfari Mark Nana Kwame, Lönnberg Tuomas

PublisherWiley-WCH

Publication year2024

JournalChemistryOpen

Journal name in sourceChemistryOpen

Journal acronymChemistryOpen

Article numbere202400088

Volume13

Issue9

ISSN2191-1363

eISSN2191-1363

DOIhttps://doi.org/10.1002/open.202400088(external)

Web address https://doi.org/10.1002/open.202400088(external)

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/393492522(external)


Abstract
Base-filling, i. e., post-synthetic furnishing of an oligonucleotide scaffold with base moieties or their analogues, is an interesting alternative to the conventional approach of sequential coupling of building blocks (modified or otherwise). Reversible attachment of the base moieties is particularly attractive as it allows the use of dynamic combinatorial chemistry and usually leads to higher fidelity. This concept article summarizes the various backbones and coupling reactions used for base-filling over the past fifteen years, discusses the impact of base stacking and pairing on efficiency and fidelity and highlights potential and realized applications.

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Last updated on 2025-17-03 at 14:13