A scientific debate: The sword that cleaves chaos of DNAzyme catalysis research

: Yan Jiaqi, Ran Meixin, Zhang Hongbo

Publisher: Publishing services by Elsevier on behalf of KeAi Communications

: 2023

: Biomedical Technology

: 4

: 21

: 23

: 2949-723X

DOI: https://doi.org/10.1016/j.bmt.2023.01.004

: https://doi.org/10.1016/j.bmt.2023.01.004

: https://research.utu.fi/converis/portal/detail/Publication/381245251

Therapeutic DNAzymes with RNA depleting effect are multifunctional building blocks for constructing biological materials. In a recent work published in Nature Chemistry, Holliger group and Chaput group had a wonderful debate base on previously reported approach for tailoring DNAzymes with high mRNA cleavage activity in mammalian cells. Their perspective pushes the catalytic mechanism investigation of DNAzymes to a new stage with more standardization and clarity.

A scientific debate_ The sword that cleaves chaos of DNAzyme catalysis research.pdf