B1 Non-refereed article in a scientific journal

A scientific debate: The sword that cleaves chaos of DNAzyme catalysis research



Authors: Yan Jiaqi, Ran Meixin, Zhang Hongbo

Publisher: Publishing services by Elsevier on behalf of KeAi Communications

Publication year: 2023

Journal: Biomedical Technology

Journal name in source: Biomedical Technology

Volume: 4

First page : 21

Last page: 23

eISSN: 2949-723X

DOI: https://doi.org/10.1016/j.bmt.2023.01.004

Web address : https://doi.org/10.1016/j.bmt.2023.01.004

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/381245251


Abstract
Therapeutic DNAzymes with RNA depleting effect are multifunctional building blocks for constructing biological materials. In a recent work published in Nature Chemistry, Holliger group and Chaput group had a wonderful debate base on previously reported approach for tailoring DNAzymes with high mRNA cleavage activity in mammalian cells. Their perspective pushes the catalytic mechanism investigation of DNAzymes to a new stage with more standardization and clarity.

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Last updated on 2024-26-11 at 22:55