Effect of toremifene on the activity of NK-cells in NZB/NZW mice

: Wärri A., Kangas L.

: 1990

: Journal of Steroid Biochemistry

: 36

: 3

: 207

: 209

: 3

: 0022-4731

DOI: https://doi.org/10.1016/0022-4731(90)90006-E(external)

: http://api.elsevier.com/content/abstract/scopus_id/0025303170(external)

The effect of toremifene on NK-cells isolated from the spleen of NZB/NZW mice was studied in comparison to tamoxifen and estradiol. Unlike estradiol but like tamoxifen, toremifene did not influence the activity of NK-cells. Low doses (0.1 and 10.0 mg/kg) of toremifene did not suppress, but a high dose of toremifene and tamoxifen (50 mg/kg for 6 weeks) suppressed the stimulating effect of human interferon alpha on the cells. © 1990.