A1 Refereed original research article in a scientific journal

Effect of toremifene on the activity of NK-cells in NZB/NZW mice



Authors: Wärri A., Kangas L.

Publication year: 1990

Journal: Journal of Steroid Biochemistry

Journal name in source: Journal of Steroid Biochemistry

Volume: 36

Issue: 3

First page : 207

Last page: 209

Number of pages: 3

ISSN: 0022-4731

DOI: https://doi.org/10.1016/0022-4731(90)90006-E

Web address : http://api.elsevier.com/content/abstract/scopus_id/0025303170


Abstract
The effect of toremifene on NK-cells isolated from the spleen of NZB/NZW mice was studied in comparison to tamoxifen and estradiol. Unlike estradiol but like tamoxifen, toremifene did not influence the activity of NK-cells. Low doses (0.1 and 10.0 mg/kg) of toremifene did not suppress, but a high dose of toremifene and tamoxifen (50 mg/kg for 6 weeks) suppressed the stimulating effect of human interferon alpha on the cells. © 1990.



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