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Effect of toremifene on the activity of NK-cells in NZB/NZW mice
Tekijät: Wärri A., Kangas L.
Julkaisuvuosi: 1990
Journal: Journal of Steroid Biochemistry
Tietokannassa oleva lehden nimi: Journal of Steroid Biochemistry
Vuosikerta: 36
Numero: 3
Aloitussivu: 207
Lopetussivu: 209
Sivujen määrä: 3
ISSN: 0022-4731
DOI: https://doi.org/10.1016/0022-4731(90)90006-E
Verkko-osoite: http://api.elsevier.com/content/abstract/scopus_id/0025303170
Tiivistelmä
The effect of toremifene on NK-cells isolated from the spleen of NZB/NZW mice was studied in comparison to tamoxifen and estradiol. Unlike estradiol but like tamoxifen, toremifene did not influence the activity of NK-cells. Low doses (0.1 and 10.0 mg/kg) of toremifene did not suppress, but a high dose of toremifene and tamoxifen (50 mg/kg for 6 weeks) suppressed the stimulating effect of human interferon alpha on the cells. © 1990.
The effect of toremifene on NK-cells isolated from the spleen of NZB/NZW mice was studied in comparison to tamoxifen and estradiol. Unlike estradiol but like tamoxifen, toremifene did not influence the activity of NK-cells. Low doses (0.1 and 10.0 mg/kg) of toremifene did not suppress, but a high dose of toremifene and tamoxifen (50 mg/kg for 6 weeks) suppressed the stimulating effect of human interferon alpha on the cells. © 1990.
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