Finnish children carrying the high-risk HLA genotype have a 45-fold increased risk of type 1 diabetes compared to peers with neutral or protective genotypes
: Taka Antti-Mathias, But Anna, Lempainen Johanna, Vatanen Tommi, Härkönen Taina, Ilonen Jorma, Knip Mikael
Publisher: Elsevier
: 2023
: Diabetes Research and Clinical Practice
: Diabetes research and clinical practice
: Diabetes Res Clin Pract
: 110256
: 197
: 0168-8227
: 1872-8227
DOI: https://doi.org/10.1016/j.diabres.2023.110256
: https://doi.org/10.1016/j.diabres.2023.110256
: https://research.utu.fi/converis/portal/detail/Publication/179032396
The association between HLA genotypes and type 1 diabetes is well known. We set out to examine incidence rates and ratios of type 1 diabetes depending on the risk afflicted by HLA genotype. Children with the high-risk genotype have a 45-fold disease risk compared to peers with neutral or protective genotypes.
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