A1 Refereed original research article in a scientific journal

Finnish children carrying the high-risk HLA genotype have a 45-fold increased risk of type 1 diabetes compared to peers with neutral or protective genotypes



Authors: Taka Antti-Mathias, But Anna, Lempainen Johanna, Vatanen Tommi, Härkönen Taina, Ilonen Jorma, Knip Mikael

Publisher: Elsevier

Publication year: 2023

Journal: Diabetes Research and Clinical Practice

Journal name in source: Diabetes research and clinical practice

Journal acronym: Diabetes Res Clin Pract

Article number: 110256

Volume: 197

ISSN: 0168-8227

eISSN: 1872-8227

DOI: https://doi.org/10.1016/j.diabres.2023.110256

Web address : https://doi.org/10.1016/j.diabres.2023.110256

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/179032396


Abstract
The association between HLA genotypes and type 1 diabetes is well known. We set out to examine incidence rates and ratios of type 1 diabetes depending on the risk afflicted by HLA genotype. Children with the high-risk genotype have a 45-fold disease risk compared to peers with neutral or protective genotypes.

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Last updated on 2025-27-03 at 21:46