Establishment of a human induced pluripotent stem cell line (TAUi008-A) derived from a multiple sclerosis patient




Lotila Johanna, Hyvärinen Tarja, Skottman Heli, Airas Laura, Narkilahti Susanna, Hagman Sanna

PublisherElsevier B.V.

2022

Stem Cell Research

Stem Cell Research

63

DOIhttps://doi.org/10.1016/j.scr.2022.102865

https://doi.org/10.1016/j.scr.2022.102865

https://research.utu.fi/converis/portal/detail/Publication/176045232



Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system where the main pathogenetic events include demyelination and axonal degeneration. Here, we generated a human induced pluripotent stem cell (hiPSC) line from peripheral blood mononuclear cells of an MS patient utilizing Sendai virus reprogramming. The produced hiPSC line expressed pluripotency markers, differentiated into three germ layers, showed a normal karyotype and was free of virus vectors, transgenes and mycoplasma. Established hiPSCs are a valuable source for studies of MS disease modeling and drug discovery.


Last updated on 2024-26-11 at 13:02